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Abstract
Background
The thalamus plays a crucial role in transmitting nociceptive information to various cortical regions involving migraine-related allodynia and photophobia. Abnormal structural and functional alterations related to the thalamus have been well established. However, it is unknown whether the brain structure and function of the thalamic subregions are differentially affected in this disorder. In this study, we aimed to clarify this issue by comparing the structure and function of 16 thalamic subregions between patients with episodic migraine (EM) and healthy controls (HCs).
Methods
Twenty-seven patients with EM and 30 sex-, age- and education-matched HCs underwent resting-state functional and structural magnetic resonance imaging scans. Functional connectivity (rsFC), grey matter volume (GMV), and diffusion tensor imaging (DTI) parameters of each subregion of the thalamus were calculated and compared between the two groups. Furthermore, correlation analyses between neuroimaging changes and clinical features were performed in this study.
Results
First, compared with HCs, patients with EM exhibited decreased rsFC between the anterior-medial-posterior subregions of the thalamus and brain regions mainly involved in the medial system of the pain processing pathway and default mode network (DMN). Second, for the whole thalamus and each of its subregions, there were no significant differences in GMV between patients with EM and HCs (P > 0.05, Bonferroni corrected). Third, there was no significant difference in DTI parameters between the two groups (P > 0.05). Finally, decreased rsFC was closely related to scores on the Hamilton Rating Scale for Anxiety (HAMA) and Big Five Inventory (BFI) scales.
Conclusion
Selective functional hypoconnectivity in the thalamic subregions provides neuroimaging evidence supporting the important role of thalamocortical pathway dysfunction in episodic migraine, specifically, that it may modulate emotion and different personality traits in migraine patients.
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Details
1 University of Science and Technology of China, Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei, China (GRID:grid.59053.3a) (ISNI:0000000121679639)
2 The Second Affiliated Hospital of Anhui Medical University, Department of Neurology, Hefei, China (GRID:grid.452696.a) (ISNI:0000 0004 7533 3408)
3 Anhui Provincial Stereotactic Neurosurgical Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China (GRID:grid.59053.3a) (ISNI:0000000121679639)
4 University of Science and Technology of China, Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei, China (GRID:grid.59053.3a) (ISNI:0000000121679639)