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Abstract
The COVID-19 pandemic is a global stressor with inter-individually differing influences on mental health trajectories. Polygenic Risk Scores (PRSs) for psychiatric phenotypes are associated with individual mental health predispositions. Elevated hair cortisol concentrations (HCC) and high PRSs are related to negative mental health outcomes. We analyzed whether PRSs and HCC are related to different mental health trajectories during the first COVID lockdown in Germany. Among 523 participants selected from the longitudinal resilience assessment study (LORA), we previously reported three subgroups (acute dysfunction, delayed dysfunction, resilient) based on weekly mental health (GHQ-28) assessment during COVID lockdown. DNA from blood was collected at the baseline of the original LORA study (n = 364) and used to calculate the PRSs of 12 different psychopathological phenotypes. An explorative bifactor model with Schmid-Leiman transformation was calculated to extract a general genetic factor for psychiatric disorders. Hair samples were collected quarterly prior to the pandemic for determining HCC (n = 192). Bivariate logistic regressions were performed to test the associations of HCC and the PRS factors with the reported trajectories. The bifactor model revealed 1 general factor and 4 sub-factors. Results indicate a significant association between increased values on the general risk factor and the allocation to the acute dysfunction class. The same was found for elevated HCC and the exploratorily tested sub-factor “childhood-onset neurodevelopmental disorders”. Genetic risk and long-term cortisol secretion as a potential indicator of stress, indicated by PRSs and HCC, respectively, predicted different mental health trajectories. Results indicate a potential for future studies on risk prediction.
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1 Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany
2 University Medical Center Mainz, Department of Psychiatry and Psychotherapy, Mainz, Germany (GRID:grid.410607.4); Leibniz Institute for Resilience Research (LIR), Mainz, Germany (GRID:grid.509458.5) (ISNI:0000 0004 8087 0005)
3 Technical University of Darmstadt, Institute of Psychology, Darmstadt, Germany (GRID:grid.6546.1) (ISNI:0000 0001 0940 1669)
4 Leibniz Institute for Resilience Research (LIR), Mainz, Germany (GRID:grid.509458.5) (ISNI:0000 0004 8087 0005)
5 University Medical Center Mainz, Department of Psychiatry and Psychotherapy, Mainz, Germany (GRID:grid.410607.4)
6 Leibniz Institute for Resilience Research (LIR), Mainz, Germany (GRID:grid.509458.5) (ISNI:0000 0004 8087 0005); University Medical Center Mainz, Institute of Physiological Chemistry, Mainz, Germany (GRID:grid.410607.4)
7 Goethe University Frankfurt, Department of Psychology, Frankfurt am Main, Germany (GRID:grid.7839.5) (ISNI:0000 0004 1936 9721); Goethe University, Brain Imaging Center, Frankfurt, Germany (GRID:grid.7839.5) (ISNI:0000 0004 1936 9721)
8 Leibniz Institute for Resilience Research (LIR), Mainz, Germany (GRID:grid.509458.5) (ISNI:0000 0004 8087 0005); Johannes Gutenberg University Mainz, Department of Clinical Psychology and Neuropsychology, Institute for Psychology, Mainz, Germany (GRID:grid.5802.f) (ISNI:0000 0001 1941 7111)
9 Leibniz Institute for Resilience Research (LIR), Mainz, Germany (GRID:grid.509458.5) (ISNI:0000 0004 8087 0005); Johannes Gutenberg University Medical Center Mainz, Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Mainz, Germany (GRID:grid.410607.4)
10 Goethe University Frankfurt, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Frankfurt, Germany (GRID:grid.7839.5) (ISNI:0000 0004 1936 9721)
11 Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany (GRID:grid.509458.5)