It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
The gene encoding beta2-adrenergic receptor (β2-AR), adrenoceptor beta 2 (ADRB2), has been reported to closely associated with various cancers. However, its role in lung adenocarcinoma (LUAD) remains controversial. This research shed light on the prognostic value of ADRB2 in LUAD and further explored its association with immune cell infiltration. ADRB2 was significantly decreased in LUAD. ADRB2 expression in LUAD was significantly correlated with gender, smoking status, T classification, and pathologic stage. Patients in the low ADRB2 expression group presented with significantly poorer overall survival (OS) and disease-specific survival (DSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) results showed that ADRB2 participates in immune response. The expression of ADRB2 was positively correlated with the infiltration level of most immune cells. Notably, ADRB2 is involved in LUAD progression partly by regulating the immune microenvironment, which may potentially serve as a significant prognostic biomarker as well as a potential drug target.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Shandong University of Traditional Chinese Medicine, First Clinical Medical College, Jinan, China (GRID:grid.464402.0) (ISNI:0000 0000 9459 9325)
2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Geriatric Medicine, Jinan, China (GRID:grid.479672.9)
3 Shandong University of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Jinan, China (GRID:grid.464402.0) (ISNI:0000 0000 9459 9325)
4 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Neurology, Jinan, China (GRID:grid.479672.9)
5 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Record Room, Jinan, China (GRID:grid.479672.9)
6 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Geriatric Medicine, Jinan, China (GRID:grid.479672.9); Shandong University of Traditional Chinese Medicine, Subject of Integrated Chinese and Western Medicine , Jinan, China (GRID:grid.464402.0) (ISNI:0000 0000 9459 9325)