Full text

Turn on search term navigation

Copyright © 2022 Ma Ting et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Objective. To study the expression and correlation of insulin receptor (INSR), insulin receptor substrate-1 (IRS-1), and programmed cell death ligand-1 (PD-L1) in nonsmall cell lung cancer (NSCLC). Methods. 45 lung cancer tissues and 30 adjacent normal tissues of NSCLC patients diagnosed in the Second Affiliated Hospital of Shandong First Medical University from June 2019 to August 2020 were selected. The expressions of INSR, IRS-1, and PD-L1 proteins in tumor tissues and adjacent tissues of NSCLC were detected by immunohistochemical staining. Results. The expression of INSR and IRS-1 in NSCLC was significantly higher than that in adjacent normal lung tissue (P<0.05). INSR expression had statistical significance with the degree of pathological differentiation of nonsmall cell carcinoma (P=0.031), but had no significant association with age, gender, pathological type, TNM stage, and lymph node metastasis status (P>0.05). There was no significant correlation between IRS-1 positive expression and NSCLC patients’ age, gender, pathological typing, degree of differentiation, TNM stage, and lymph node metastasis (P>0.05). PD-L1 positive expression was correlated with lymph node metastasis of NSCLC (P=0.028), while there was no significant correlation with gender, age, pathological type, TNM stage, and pathological differentiation degree of NSCLC patients (P>0.05). Spearman correlation analysis showed that PD-L1 protein expression had a significant positive correlation with IRS-1 protein expression (r=0.373), but was not correlated with the expression of INSR protein. Conclusion. IRS-1 may be involved in the regulation of PD-L1 expression and mediate the occurrence of tumor immune escape, which is expected to become a new target for NSCLC immunotherapy and provide new clinical evidence for immunosuppressive therapy.

Details

Title
Correlation Study on the Expression of INSR, IRS-1, and PD-L1 in Nonsmall Cell Lung Cancer
Author
Ma, Ting 1   VIAFID ORCID Logo  ; Yu-e, Miao 2 ; Feng-xiu, Yu 3 ; Guang-cai Luo 4 ; Xu, Xin 4 ; Li-xia, Xiao 5 ; Guo-qing, Zhang 4   VIAFID ORCID Logo  ; Chang, Jin 4   VIAFID ORCID Logo 

 Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an, 271000 Shandong Province, China; The Second Affiliated Hospital of Shandong First Medical University, Tai’an, 271000 Shandong Province, China 
 Department of Chemotherapy, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China 
 Basic Medical College, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, 271000 Shandong Province, China 
 Department of Radiation Oncology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China 
 The Second Affiliated Hospital of Shandong First Medical University, Tai’an, 271000 Shandong Province, China 
Editor
Ningke Ruan
Publication year
2022
Publication date
2022
Publisher
John Wiley & Sons, Inc.
ISSN
16878450
e-ISSN
16878469
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2725126141
Copyright
Copyright © 2022 Ma Ting et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.