Abstract

Background

Liver transplantation (LT) is the best treatment for selected patients with cirrhosis and small hepatocellular carcinoma (HCC) who are not candidates for resection. The proinflammatory effects of systemic inflammatory response have been linked with HCC. Therefore, the measurement of inflammatory markers represents a significant tool to limit recurrence after LT.

Results

There are eleven patients with HCC recurrence post-transplantation. Pre-transplantation AFP can predict HCC recurrence with the best cutoff value of > 17.8 ng/ml with a sensitivity of 82% and specificity of 70%. Post-transplantation CRP can predict HCC recurrence with the best cutoff value of > 0.85 (mg/dl) with a sensitivity of 73% and specificity of 71%. Other inflammatory markers NLR and PLR were not significant in predicting HCC recurrence. Moreover, HCC recurrence significantly affects the outcome of patients undergoing LT (p value < 0.001) with a worse prognosis.

Conclusion

Our results showed additional benefits of inflammatory markers as CRP to standard parameters in predicting HCC recurrence to refine recipient selection and achieve better survival outcomes post-LT.

Details

Title
Role of inflammatory markers in predicting hepatocellular carcinoma recurrence after liver transplantation
Author
Badwei, Nourhan 1   VIAFID ORCID Logo  ; Monsef, Waheed A. 1 ; Montasser, Iman 1 ; Bahaa, Mohamed 2 ; El Meteini, Mahmoud 2 ; Kamel, Shimaa Y. 1 

1  Ain Shams University, Tropical Medicine, Gastroenterology and Hepatology, Faculty of Medicine, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570) 
2  Ain Shams University, Hepatobiliary Surgery, Faculty of Medicine, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570) 
Pages
40
Publication year
2021
Publication date
Dec 2021
Publisher
Springer Nature B.V.
ISSN
20906218
e-ISSN
20906226
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43066-021-00105-8
ProQuest document ID
2729512575
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.