Abstract

Background

Hypogonadotropic hypogonadism (HH) is a rare condition in which there is gonadal hypofunction due to absence of gonadotropin drive. In this condition, there are very low serum levels of gonadotropins. Pituitary gland may itself have some disease or disorder, or there may be loss of gonadotropin-releasing hormone (GnRH) pulses from the hypothalamus. The pharmacological interventions in HH women formed the basis for superovulation strategies for assisted reproduction techniques (ART) with a special reference to the role of LH and its impact on oocyte and embryo quality.

Results

The medians ±inter quartile ranges for number of oocytes retrieved, number of MII oocytes, and number of embryos transferred were 5±7, 4±3, and 3±1 respectively. The pregnancy rate was 31.5% for this group of patients. The live birth rate and miscarriage rate were 21% and 11.5% respectively.

Conclusion

The reproductive outcomes of patients of hypogonadotrophic hypogonadism are reasonable after ICSI and clinical trials are recommended to corroborate this concern.

Details

Title
Reproductive outcomes in women with hypogonadotrophic hypogonadism, a case series study
Author
Abdelaal, Ahmed Elsayed 1 ; Behery, Mohamed Atef 1   VIAFID ORCID Logo  ; Abdelkawi, Ahmed Farouk 2 

1  Al Azhar University, Reproduction Unit, The International Islamic Institute for Population Studies and Research, Cairo, Egypt (GRID:grid.411303.4) (ISNI:0000 0001 2155 6022) 
2  Assiut University, Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut, Egypt (GRID:grid.252487.e) (ISNI:0000 0000 8632 679X) 
Publication year
2021
Publication date
Dec 2021
Publisher
Springer Nature B.V.
ISSN
11105690
e-ISSN
20903251
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43043-021-00055-6
ProQuest document ID
2729533414
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.