Abstract
Background
Contemporary data regarding the characteristics, treatment and outcomes of patients with atrial fibrillation (AF) are needed. We aimed to assess these data and guideline adherence in the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) long-term general registry.
Methods
We analysed 967 patients from the EORP-AF long-term general registry included in the Netherlands and Belgium from 2013 to 2016. Baseline and 1‑year follow-up data were gathered.
Results
At baseline, 887 patients (92%) received anticoagulant treatment. In 88 (10%) of these patients, no indication for chronic anticoagulant treatment was present. A rhythm intervention was performed or planned in 52 of these patients, meaning that the remaining 36 (41%) were anticoagulated without indication. Forty patients were not anticoagulated, even though they had an indication for chronic anticoagulation. Additionally, 63 of the 371 patients (17%) treated with a non-vitamin K antagonist oral anticoagulant (NOAC) were incorrectly dosed. In total, 50 patients (5%) were overtreated and 89 patients (9%) were undertreated. However, the occurrence of major adverse cardiac and cerebrovascular events (MACCE) was still low with 4.2% (37 patients).
Conclusions
Overtreatment and undertreatment with anticoagulants are still observable in 14% of this contemporary, West-European AF population. Still, MACCE occurred in only 4% of the patients after 1 year of follow-up.
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Details
1 Maastricht University Medical Center + (MUMC+), Department of Cardiology, Maastricht, The Netherlands (GRID:grid.412966.e) (ISNI:0000 0004 0480 1382); Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands (GRID:grid.5012.6) (ISNI:0000 0001 0481 6099)
2 Jeroen Bosch Hospital, Department of Cardiology, ’s Hertogenbosch, The Netherlands (GRID:grid.413508.b) (ISNI:0000 0004 0501 9798)
3 CHU Namur, Department of Cardiology, Yvoir, Belgium (GRID:grid.413508.b)
4 Medisch Spectrum Twente, Department of Cardiology, Enschede, The Netherlands (GRID:grid.415214.7) (ISNI:0000 0004 0399 8347)
5 Academic Medical Centre Amsterdam, Department of Cardiology, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431)
6 VieCuri Medical Center, Department of Cardiology, Venlo, The Netherlands (GRID:grid.416856.8) (ISNI:0000 0004 0477 5022)
7 Tjongerschans Hospital Heerenveen, Department of Cardiology, Heerenveen, The Netherlands (GRID:grid.416856.8)
8 Ziekenhuis Groep Twente, Department of Cardiology, Hengelo, The Netherlands (GRID:grid.417370.6) (ISNI:0000 0004 0502 0983)
9 Flevo Hospital, Department of Cardiology, Almere, The Netherlands (GRID:grid.440159.d) (ISNI:0000 0004 0497 5219)
10 Ommelander Hospital Group, Department of Cardiology, Delfzijl, The Netherlands (GRID:grid.440159.d)
11 Erasmus Medical Center, Department of Cardiology, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:000000040459992X)
12 Tjongerschans Hospital Heerenveen, Department of Cardiology, Heerenveen, The Netherlands (GRID:grid.440159.d)
13 Jessa Hospital, Department of Cardiology, Hasselt, Belgium (GRID:grid.414977.8) (ISNI:0000 0004 0578 1096)
14 CHU Tivoli, Department of Cardiology, La Louvière, Belgium (GRID:grid.414977.8)
15 CHR Citadelle, Department of Cardiology, Liège, Belgium (GRID:grid.413914.a) (ISNI:0000 0004 0645 1582)
16 CHC St Joseph, Department of Cardiology, Liège, Belgium (GRID:grid.433083.f) (ISNI:0000 0004 0608 8015)
17 CHU Liège, Department of Cardiology, Liège, Belgium (GRID:grid.411374.4) (ISNI:0000 0000 8607 6858)
18 University of Birmingham, Institute of Cardiovascular Sciences, Birmingham, UK (GRID:grid.6572.6) (ISNI:0000 0004 1936 7486); Aalborg University, Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg, Denmark (GRID:grid.5117.2) (ISNI:0000 0001 0742 471X)
19 University of Modena and Reggio Emilia, Modena University Hospital, Department of Cardiology, Modena, Italy (GRID:grid.7548.e) (ISNI:0000000121697570)
20 Maastricht University Medical Center + (MUMC+), Department of Cardiology, Maastricht, The Netherlands (GRID:grid.412966.e) (ISNI:0000 0004 0480 1382)
21 Cliniques du Sud-Luxembourg, Arlon and Clinique Ste Thérèse, Department of Cardiology, Bastogne, Belgium (GRID:grid.477060.2) (ISNI:0000 0004 0608 759X)