Abstract
Background
Autism Spectrum Disorders (ASD) are a group of neurodevelopmental disabilities with unknown etiology. Recent studies suggest the contribution of immune dysfunction and oxidative stress in its pathophysiology. The present study aimed to investigate the serum level of thioredoxin (Trx), as a marker of oxidative stress and some inflammatory cytokines, and to evaluate their role in children with ASD.
Results
Concentrations of Trx, IL-1β, IL-8, and TNF-α were significantly higher in children with ASD compared with matched controls. There were no association between cytokine levels and the severity of clinical manifestations, according to CARS classification of severity.
Conclusion
The present study provides support for the idea that physiological abnormalities, such as oxidative stress and immune dysfunction, may contribute in the pathophysiology of ASD.
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Details
1 Al-Azhar University, Pediatric Department, Faculty of Medicine for Girls, Cairo, Egypt (GRID:grid.411303.4) (ISNI:0000 0001 2155 6022)
2 National Research Centre, Child Health Department, Cairo, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157)
3 National Research Centre, Medical Biochemistry Department, Cairo, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157)
4 Al-Azhar University, Psychiatry Department, Faculty of Medicine for Girls, Cairo, Egypt (GRID:grid.411303.4) (ISNI:0000 0001 2155 6022)
5 Al-Mansoura University, Psychiatry Department, Faculty of Medicine, Mansoura, Egypt (GRID:grid.10251.37) (ISNI:0000000103426662)
6 Aswan University, Pediatric Department, Faculty of Medicine, Aswan, Egypt (GRID:grid.417764.7) (ISNI:0000 0004 4699 3028)