Abstract
In 2011 the Netherlands Heart Foundation allocated funding (CVON, Cardiovasculair Onderzoek Nederland) to stimulate collaboration between clinical and preclinical researchers on specific areas of research. One of those areas involves genetic heart diseases, which are frequently caused by pathogenic variants in genes that encode sarcomere proteins. In 2014, the DOSIS (Determinants of susceptibility in inherited cardiomyopathy: towards novel therapeutic approaches) consortium was initiated, focusing their research on secondary disease hits involved in the onset and progression of cardiomyopathies. Here we highlight several recent observations from our consortium and collaborators which may ultimately be relevant for clinical practice.
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1 University Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, The Netherlands
2 Amsterdam UMC, Vrije Universiteit, Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227)
3 University Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, The Netherlands (GRID:grid.12380.38)
4 University Medical Center Rotterdam, Erasmus MC, Department of Cardiology, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:000000040459992X)
5 University Medical Centre Utrecht, Utrecht University, Department of Cardiology, Division Heart & Lungs, Utrecht, The Netherlands (GRID:grid.5477.1) (ISNI:0000000120346234)
6 University Medical Centre Utrecht, Utrecht University, Department of Genetics, Utrecht, The Netherlands (GRID:grid.5477.1) (ISNI:0000000120346234)