Abstract
Unlike observational trials, randomized controlled trials in sepsis are faced with accounting for this urgency while providing time to stabilize the patient, update family, obtain and document informed consent, randomly assign patients, and administer the intervention (or placebo). Furthermore, in patients who received vitamin C, thiamine and steroids in sepsis within the Centers for Medicare & Medicaid Services Studies 6-h sepsis bundle time line, we found that the APACHE-adjusted ICU mortality was significantly reduced when compared with that of patients who received standard care (odds ratio [OR] 0.075 [0.0, 0.59], P <0.01). [...]we strongly suggest a planned subgroup analysis evaluating the relationship between timing of therapy and clinical outcomes.
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Details
1 University of Wisconsin, Department of Medicine, Madison, USA (GRID:grid.28803.31) (ISNI:0000 0001 0701 8607)
2 University of Wisconsin School of Medicine and Public Health, Department of Anesthesiology, Madison, USA (GRID:grid.14003.36) (ISNI:0000 0001 2167 3675)