Abstract

The mechanisms of diabetogenesis in children remain largely obscure. This study aimed to determine the impact of vitamin D and calcium supplementation on pancreatic β-cells function in terms of insulin secretion and sensitivity. This was a quasi-experimental study involving 30 obese and prepubescent Tunisian children (57% boys). During three months, the children received calcium and vitamin D supplementation at therapeutic doses. An oral glucose tolerance test (OGTT) was performed at the beginning and at the end of the study. The following metabolic definitions were applied: i) hyperinsulinism: insulinemia sum > 300 μ UI/ml during OGTT, ii) insulin-resistance: homeostatic model assessment of insulin-resistance > 2, iii) normal glycaemic profile: normal plasma levels during OGTT without any spike, and iv) pancreatic β-cells dysfunction reversibility: disappearance of the aforementioned disorders. The means ± standard-deviation of age and body mass index were 10.87 ± 1.9 years, and 30.17 ± 4.99 kg/m2, respectively. All children were at the stage of hyperinsulinism associated with insulin-resistance. These disturbances were noted even in children having a normal glycaemic profile at OGTT. After calcium and vitamin D supplementation, glycaemic profile as well as insulin-secretion improved significantly (p < 0.0001). Hyperinsulinism and insulin-resistance decreased significantly by 56.67% (p < 0.0001) and 70.00% (p < 0.0001), respectively. Complete reversibility of these two disorders was noted in 26.6% of children. To conclude, in obese and prepubescent children, vitamin D and calcium supplementation led to the reversibility of the pancreatic β-cells dysfunction.

Details

Title
Reversibility of pancreatic β-cells dysfunction after vitamin D and calcium supplementation: a pilot study in a population of obese and prepubescent North-African children
Author
Gaddas, Meriem 1   VIAFID ORCID Logo  ; Latiri, Imed 2   VIAFID ORCID Logo  ; Raoudha Kebaili 3   VIAFID ORCID Logo  ; Kacem, Ilhem 4   VIAFID ORCID Logo  ; Jaballah, Nesrine 3   VIAFID ORCID Logo  ; Maatoug, Jihene 5 ; Salaani, Mohamed 3 ; Boughammoura, Lamia 3   VIAFID ORCID Logo  ; Helmi Ben Saad 6 

 Faculté de Médecine de Sousse, Service de Physiologie et Explorations Fonctionnelles, Université de Sousse, Sousse, Tunisie; University of Sousse, Farhat HACHED Hospital, Departement of physiology and functional explorations, Sousse, Tunisia Sousse 
 Faculté de Médecine de Sousse, Service de Physiologie et Explorations Fonctionnelles, Université de Sousse, Sousse, Tunisie; Laboratoire de recherche LR12SP09 «Insuffisance cardiaque», Université de Sousse, Hôpital Farhat HACHED, Sousse, Tunisie 
 Paediatrics Department, Farhat HACHED Hospital of Sousse, University of Sousse, Sousse, Tunisia 
 Basic Health Center «Sousse Jawhara”, Outpatient consultation, Sousse, Tunisia 
 Epidemiology Department, Farhat HACHED Hospital of Sousse, University of Sousse, Sousse, Tunisia 
 Faculté de Médecine de Sousse, Service de Physiologie et Explorations Fonctionnelles, Université de Sousse, Sousse, Tunisie; University of Sousse, Farhat HACHED Hospital, Departement of physiology and functional explorations, Sousse, Tunisia Sousse; Laboratoire de recherche LR12SP09 «Insuffisance cardiaque», Université de Sousse, Hôpital Farhat HACHED, Sousse, Tunisie 
Publication year
2022
Publication date
Dec 2022
Publisher
Taylor & Francis Ltd.
ISSN
19932820
e-ISSN
18196357
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2734421666
Copyright
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons  Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.