Abstract

In brain tissue of three harbor seals of the German North Sea coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627K variants detected in these cases.

Details

Title
Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
Author
Postel, Alexander 1   VIAFID ORCID Logo  ; King, Jacqueline 2   VIAFID ORCID Logo  ; Kaiser, Franziska K 3   VIAFID ORCID Logo  ; Kennedy, Johanna 1 ; Lombardo, Mara Sophie 4 ; Reineking, Wencke 4   VIAFID ORCID Logo  ; de le Roi, Madeleine 4   VIAFID ORCID Logo  ; Harder, Timm 2   VIAFID ORCID Logo  ; Pohlmann, Anne 2   VIAFID ORCID Logo  ; Gerlach, Thomas 3 ; Rimmelzwaan, Guus 3   VIAFID ORCID Logo  ; Rohner, Simon 5   VIAFID ORCID Logo  ; Striewe, Lotte C 5   VIAFID ORCID Logo  ; Gross, Stephanie 5   VIAFID ORCID Logo  ; Schick, Luca A 5   VIAFID ORCID Logo  ; Klink, Jana C 5   VIAFID ORCID Logo  ; Kramer, Katharina 6 ; Albert D M E Osterhaus 3   VIAFID ORCID Logo  ; Beer, Martin 2   VIAFID ORCID Logo  ; Baumgärtner, Wolfgang 4   VIAFID ORCID Logo  ; Siebert, Ursula 5   VIAFID ORCID Logo  ; Becher, Paul 1   VIAFID ORCID Logo 

1  Institute of Virology, University of Veterinary Medicine, Hannover, Germany 
2  Institute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald, Germany 
3  Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany 
4  Institute of Pathology, University of Veterinary Medicine, Hannover, Germany 
5  Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine, Hannover, Germany 
6  Landeslabor Schleswig- Holstein, Neumünster, Germany 
Pages
725-729
Publication year
2022
Publication date
Dec 2022
Publisher
Taylor & Francis Ltd.
e-ISSN
22221751
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/22221751.2022.2043726
ProQuest document ID
2748038585
Copyright
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.