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Abstract
Sodium alginate (SA) has been widely used in various fields of daily life. However, the lack of antibacterial properties of SA limits its further application. In this work, we successfully developed the antimicrobial SA derivative through the covalent coupling between organosilane quaternary ammonium salt DC-5700 (TSA) and SA using a one-pot reaction. The corresponding structures, molecular weights, morphologies, thermal properties, and viscosity of the SA-TSA samples were comprehensively characterized by FTIR, GPC, SEM, TGA, and rotational rheometer. The best antibacterial efficiency against Staphylococcus aureus and Escherichia coli can reach up to 99.6% and 99.3%, respectively. Specifically, great biocompatibility (> 80%) was observed when the concentration of best antibacterial SA-TSA3 was < 0.50 g/mL. Moreover, the antibacterial potential utility of antibacterial SA-TSA3 was demonstrated by the fabrication of SA beads. Finally, this antibacterial material of SA-TSA3 was expected to show great potential application in biomedical or textile fields.
Details
1 Hainan University, Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology, Haikou, China (GRID:grid.428986.9) (ISNI:0000 0001 0373 6302)
2 Nankai University, College of Life Sciences, Tianjin, China (GRID:grid.216938.7) (ISNI:0000 0000 9878 7032)
3 Beijing Institute of Graphic Communication, Beijing Engineering Research Center of Printed Electronics, Beijing, China (GRID:grid.443253.7) (ISNI:0000 0004 1791 5856)
4 The First Affiliated Hospital of Hainan Medical University, Department of Joint Surgery, Haikou, China (GRID:grid.443397.e) (ISNI:0000 0004 0368 7493)