Extensive literature search on grayanotoxins and 5-hydroxymethylfurfural

Abstract

An extensive literature search to identify and collect studies related to the toxicity of grayanotoxins and 5-hydroxymethylfurfural (5-HMF) was performed in the three databases PubMed, Web of Science and SciFinder^® for six and four Areas, respectively. After combination of the searches from the three databases and removal of the duplicates, the total number of references for the grayanotoxins was 652 and for 5-HMF Area 1b was 3,862, for Area 2b was 37, for Area 3b was 221 and for Area 4b was 500. The evaluation of all retrieved references for relevance by screening the title and abstract (if available) and applying eligibility criteria (inclusion/exclusion) resulted in a total number of relevant references for the grayanotoxins for Area 1a of 71, for Area 2a of 3, for Area 3a of 5, for Area 4a of 75, for Area 5a of 141, and for Area 6a of 78 and for 5-HMF for Area 1b of 55, for Area 2b of 14, for Area 3b of 15 and for Area 4b of 8.