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Abstract
Fatty acids (FAs) play an essential role as mediators of cell signaling and signal transduction, affecting metabolic homeostasis and determining meat quality in pigs. However, FAs are transformed by the action of several genes, such as those encoding desaturases and elongases of FAs in lipogenic tissues. The aim of the current work was to identify candidate genes, biological processes, and pathways involved in the modulation of intramuscular FA profile from longissimus dorsi muscle. FA profile by gas chromatography of methyl esters and gene expression by RNA-Seq were determined in 129 Iberian × Duroc backcrossed pigs. An association analysis between the muscle transcriptome and its FA profile was performed, followed by a concordance and functional analysis. Overall, a list of well-known (e.g., PLIN1, LEP, ELOVL6, SC5D, NCOA2, ACSL1, MDH1, LPL, LGALS12, TFRC, GOT1, and FBP1) and novel (e.g., TRARG1, TANK, ENSSSCG00000011196, and ENSSSCG00000038429) candidate genes was identified, either in association with specific or several FA traits. Likewise, several of these genes belong to biological processes and pathways linked to energy, lipid, and carbohydrate metabolism, which seem determinants in the modulation of FA compositions. This study can contribute to elucidate the complex relationship between gene expression and FA profile in pig muscle.
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1 Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Plant and Animal Genomics, Bellaterra, Spain; Universitat Autònoma de Barcelona, Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Bellaterra, Spain (GRID:grid.7080.f) (ISNI:0000 0001 2296 0625)
2 Institut de Recerca y Tecnologia Agraroalimentàries (IRTA), Departament de Genètica i Millora Animal, Caldes de Montbui, Spain (GRID:grid.7080.f)
3 Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Plant and Animal Genomics, Bellaterra, Spain (GRID:grid.7080.f)
4 Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Plant and Animal Genomics, Bellaterra, Spain (GRID:grid.7080.f); Universitat Autònoma de Barcelona, Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Bellaterra, Spain (GRID:grid.7080.f) (ISNI:0000 0001 2296 0625)
5 Barcelona Institute of Science and Technology, CNAG-CRG, Centre for Genomic Regulation, Barcelona, Spain (GRID:grid.473715.3) (ISNI:0000 0004 6475 7299)
6 Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Plant and Animal Genomics, Bellaterra, Spain (GRID:grid.473715.3); Universitat Autònoma de Barcelona, Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Bellaterra, Spain (GRID:grid.7080.f) (ISNI:0000 0001 2296 0625)