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Abstract
Background
We investigated the composition of the gluteal (gluteus maximus, medius, and minimus) and quadriceps (rectus femoris, vastus lateralis, medialis, and intermedius) muscle groups and its associations with femoral bone marrow using chemical shift encoding-based water-fat magnetic resonance imaging (CSE-MRI) to improve our understanding of muscle-bone interaction.
Methods
Thirty healthy volunteers (15 males, aged 30.5 ± 4.9 years [mean ± standard deviation]; 15 females, aged 29.9 ± 7.1 years) were recruited. A six-echo three-dimensional spoiled gradient-echo sequence was used for 3-T CSE-MRI at the thigh and hip region. The proton density fat fraction (PDFF) of the gluteal and quadriceps muscle groups as well as of the femoral head, neck, and greater trochanter bone marrow were extracted and averaged over both sides.
Results
PDFF values of all analysed bone marrow compartments were significantly higher in men than in women (p ≤ 0.047). PDFF values of the analysed muscles showed no significant difference between men and women (p ≥ 0.707). After adjusting for age and body mass index, moderate significant correlations of PDFF values were observed between the gluteal and quadriceps muscle groups (r = 0.670) and between femoral subregions (from r = 0.613 to r = 0.655). Regarding muscle-bone interactions, only the PDFF of the quadriceps muscle and greater trochanter bone marrow showed a significant correlation (r = 0.375).
Conclusions
The composition of the muscle and bone marrow compartments at the thigh and hip region in young, healthy subjects seems to be quite distinct, without evidence for a strong muscle-bone interaction.
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Details
1 Technische Universität München, Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)
2 Technische Universität München, Department of Sport and Health Sciences, 80992 Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)
3 Technische Universität München, Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966); Technische Universität München, Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, 81675 Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)
4 Technische Universität München, Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966); Technische Universität München, TUM-Neuroimaging Center, Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)
5 Technische Universität München, Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, 81675 Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)