Content area
Abstract
The measurement of 5-fluorouracil in body fluids is important due to the side effects of this drug that causes neurotoxicity in humans. In this direct, an electrochemical sensor based on the screen-printed electrode (SPE) with cobalt sulfide-graphene nanocomposite (CosGr) was developed for the determination of 5-fluorouracil. The CosGr-SPE presents a wide linear range from 0.1 µM to 600 µM with LOD of 0.04 µM. The real sample analysis results confirm that the CosGr/SPE is appropriate for detection of fluorouracil in real samples. This developed electrochemical sensor offers acceptable reproducibility, repeatability, sensitivity and low limit of detection toward 5-fluorouracil.
Details
Title
Electrochemical sensor for fluorouracil determination using screen-printed cobalt sulfide-graphene composite electrode
Author
Khoshroo, Alireza 1 ; Hosseinzadeh, Laleh 2 ; Ehrlich, Hermann 3 ; Ahmadi, Farhad 4 ; Rahimi-Nasrabadi, Mehdi 5
1 Hamadan University of Medical Sciences, Nutrition Health Research center, Hamadan, Iran (GRID:grid.411950.8) (ISNI:0000 0004 0611 9280)
2 Islamic Azad University, Department of Chemistry, Dehloran Branch, Dehloran, Iran (GRID:grid.411950.8)
3 TU Bergakademie Freiberg, Institute for Electronics and Sensor Materials, Freiberg, Germany (GRID:grid.6862.a) (ISNI:0000 0001 0805 5610); Adam Mickiewicz University, Center for Advanced Technology, Poznan, Poland (GRID:grid.5633.3) (ISNI:0000 0001 2097 3545)
4 Iran University of Medical Sciences, Razi Drug Research Center, Tehran, Iran (GRID:grid.411746.1) (ISNI:0000 0004 4911 7066)
5 TU Bergakademie Freiberg, Institute for Electronics and Sensor Materials, Freiberg, Germany (GRID:grid.6862.a) (ISNI:0000 0001 0805 5610); University of Tehran, Center of Excellence in Electrochemistry, School of Chemistry, Tehran, Iran (GRID:grid.46072.37) (ISNI:0000 0004 0612 7950)
1 Hamadan University of Medical Sciences, Nutrition Health Research center, Hamadan, Iran (GRID:grid.411950.8) (ISNI:0000 0004 0611 9280)
2 Islamic Azad University, Department of Chemistry, Dehloran Branch, Dehloran, Iran (GRID:grid.411950.8)
3 TU Bergakademie Freiberg, Institute for Electronics and Sensor Materials, Freiberg, Germany (GRID:grid.6862.a) (ISNI:0000 0001 0805 5610); Adam Mickiewicz University, Center for Advanced Technology, Poznan, Poland (GRID:grid.5633.3) (ISNI:0000 0001 2097 3545)
4 Iran University of Medical Sciences, Razi Drug Research Center, Tehran, Iran (GRID:grid.411746.1) (ISNI:0000 0004 4911 7066)
5 TU Bergakademie Freiberg, Institute for Electronics and Sensor Materials, Freiberg, Germany (GRID:grid.6862.a) (ISNI:0000 0001 0805 5610); University of Tehran, Center of Excellence in Electrochemistry, School of Chemistry, Tehran, Iran (GRID:grid.46072.37) (ISNI:0000 0004 0612 7950)
Pages
519
Publication year
2023
Publication date
Feb 2023
ISSN
09574522
e-ISSN
1573482X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2775334248
Copyright
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.