It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Optimal antiplatelet therapy after endovascular therapy (EVT) for peripheral artery disease is controversial. This trial aimed to evaluate whether sarpogrelate plus aspirin was non-inferior for preventing early restenosis after femoropopliteal (FP) EVT compared to clopidogrel plus aspirin. In this open-label, prospective randomized trial, 272 patients were enrolled after successful EVT for FP lesions. Patients in each group received aspirin 100 mg and clopidogrel 75 mg or sarpogrelate 300 mg orally once per day for 6 months. The primary outcome was target lesion restenosis at 6 months, tested for noninferiority. Patient characteristics and EVT patterns were similar, except for increased inflow procedures in the sarpogrelate group and increased outflow procedures in the clopidogrel group. The sarpogrelate group showed a tendency of less restenosis at 6 months than the clopidogrel group (13.0% vs. 19.1%, difference 6.1 percentage points, 95% CI for noninferiority − 0.047 to 0.169). Secondary endpoints related to safety outcomes were rare in both groups. Risks of target lesion restenosis of the two intervention arm were uniform across most major subgroups except for those with coronary artery disease. In conclusion, Sarpogrelate plus aspirin is non-inferior to clopidogrel plus aspirin in preventing early restenosis after FP EVT. Larger multi-ethnic trials are required to generalize these findings.
Trial registration: National Institutes of Health Clinical Trials Registry (ClinicalTrials.gov identifier: NCT02959606; 09/11/2016).
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Seoul National University Hospital, Division of Vascular Surgery, Department of Surgery, Seoul, Korea (GRID:grid.412484.f) (ISNI:0000 0001 0302 820X); Seoul National University College of Medicine, Seoul, South Korea (GRID:grid.31501.36) (ISNI:0000 0004 0470 5905)
2 Seoul National University College of Medicine, Seoul, South Korea (GRID:grid.31501.36) (ISNI:0000 0004 0470 5905); Bundang Seoul National University Hospital, Division of Vascular Surgery, Seongnam, South Korea (GRID:grid.412484.f) (ISNI:0000 0001 0302 820X)
3 Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, South Korea (GRID:grid.31501.36) (ISNI:0000 0004 0470 5905)
4 Gangnam Severance Hospital, Yonsei University College of Medicine, Department of Cardiovascular Surgery, Seoul, South Korea (GRID:grid.15444.30) (ISNI:0000 0004 0470 5454)
5 Pusan National University, Pusan National University Yangsan Hospital, Division of Vascular and Endovascular Surgery, Department of Surgery, School of Medicine, Yangsan, South Korea (GRID:grid.412591.a) (ISNI:0000 0004 0442 9883)
6 Seoul National University College of Medicine, Seoul, South Korea (GRID:grid.31501.36) (ISNI:0000 0004 0470 5905); Seoul Metropolitan Government–Seoul National University Boramae Medical Center, Department of Surgery, Seoul, South Korea (GRID:grid.484628.4) (ISNI:0000 0001 0943 2764)
7 Gil Hospital, Gachon University of Medicine and Science, Department of Surgery, Incheon, South Korea (GRID:grid.411652.5)
8 Korea University Hospital, Department of Surgery, Seoul, South Korea (GRID:grid.411134.2) (ISNI:0000 0004 0474 0479)
9 Yeungnam University Medical Center, Department of Surgery, Daegu, South Korea (GRID:grid.413040.2) (ISNI:0000 0004 0570 1914)
10 Asan Medical Center, Division of Vascular Surgery, Department of Surgery, Seoul, South Korea (GRID:grid.413967.e) (ISNI:0000 0001 0842 2126)
11 Kyung Hee University, Department of Surgery, College of Medicine, Seoul, South Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818)
12 Samsung Medical Center, Sungkyunkwan University School of Medicine, Division of Vascular Surgery, Department of Surgery, Seoul, South Korea (GRID:grid.414964.a) (ISNI:0000 0001 0640 5613)