Abstract

[...]there is an urgent need to investigate the safety and humoral immune responses of inactivated vaccines in cancer patients. [...]although the overall frequency of RBD+ MBCs was higher in cancer patients, immune memory was impaired. [...]an assessment of the third “booster” dose and immunity against variants of concerns was not performed, which hindered further analysis, such as the immunity against Delta or Omicrons variants after inactivated vaccination. [...]only patients with solid tumors were included in our study, while patients with hematologic malignancies were excluded, which might have impacted the results, given the higher immunosuppressive status of the latter [ 10].

Details

Title
Weakened humoral immune responses of inactivated SARS-CoV-2 vaccines in patients with solid tumors
Author
Chen, Zhiwei 1 ; Zhu, Peng 2 ; Liu, Zuojin 3 ; Zhu, Bin 4 ; Yin, Guobing 5 ; Jia Ming 5 ; Song, Rui 1 ; Pan, Qingbo 1 ; Li, Tong 2 ; Jiang, Xingwei 6 ; Wang, Bing 4 ; Liu, Shuaibin 6 ; Cai, Hongxing 2 ; Wang, Jingjie 2 ; Han, Yuling 5 ; Lin, Zijing 5 ; Yang, Hong 6 ; Chen, Min 1 ; Peng, Mingli 1 ; Hu, Lina 6 ; Cai, Dachuan 1 ; Ren, Hong 1   VIAFID ORCID Logo 

1  Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China 
2  Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China 
3  Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China 
4  Department of Thoracic and Cardiovascular Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China 
5  Department of Breast and Thyroid Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China 
6  Department of Gynaecology and Obstetrics, Reproductive Medicine Center, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China 
Pages
280-284
Section
LETTERS TO THE EDITOR
Publication year
2023
Publication date
Feb 2023
Publisher
John Wiley & Sons, Inc.
e-ISSN
2523-3548
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1002/cac2.12368
ProQuest document ID
2775930556
Copyright
© 2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.