Abstract

Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.

Details

Title
Impact of microbial genome completeness on metagenomic functional inference
Author
Eisenhofer, Raphael 1 ; Odriozola, Iñaki 1   VIAFID ORCID Logo  ; Alberdi, Antton 1   VIAFID ORCID Logo 

1  University of Copenhagen, Center for Evolutionary Hologenomics, Globe Institute, Copenhagen, Denmark (GRID:grid.5254.6) (ISNI:0000 0001 0674 042X) 
Pages
12
Publication year
2023
Publication date
Dec 2023
Publisher
Oxford University Press
e-ISSN
27306151
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s43705-023-00221-z
ProQuest document ID
2777202046
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.