Abstract

An algorithm to describe patterns of intermittent oral corticosteroid use in the UK (n = 476,167) found that one-third of patients receiving intermittent oral corticosteroids for asthma only had short gaps (<90 days) between oral corticosteroid prescriptions sometime during follow-up. The increasing frequency pattern was more likely in patients with greater asthma severity and with more short-acting β2-agonist use at baseline. Our approach may provide a clinically relevant representation of intermittent oral corticosteroid use in asthma.

Details

Title
Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma
Author
Haughney, John 1 ; Tran, Trung N. 2   VIAFID ORCID Logo  ; Heatley, Heath 3 ; Bourdin, Arnaud 4 ; Menzies-Gow, Andrew 5 ; Jackson, David J. 6 ; Maslova, Ekaterina 7 ; Chapaneri, Jatin 7 ; Skinner, Derek 3 ; Carter, Victoria 3   VIAFID ORCID Logo  ; Chan, Jeffrey Shi Kai 3 ; Price, David 8   VIAFID ORCID Logo 

1  NHS Clinical Research Facilities, Glasgow, UK 
2  AstraZeneca, Gaithersburg, USA (GRID:grid.418152.b) (ISNI:0000 0004 0543 9493) 
3  Observational and Pragmatic Research Institute, Midview City, Singapore (GRID:grid.500407.6) 
4  Montpellier University Hospitals, Arnaud de Villeneuve Hospital, Department of Respiratory Diseases, Montpellier, France (GRID:grid.413745.0) (ISNI:0000 0001 0507 738X) 
5  Royal Brompton & Harefield Hospitals, UK Severe Asthma Network and National Registry, London, UK (GRID:grid.439338.6) (ISNI:0000 0001 1114 4366) 
6  King’s College London, UK Severe Asthma Network and National Registry, Guy’s and St Thomas’ NHS Trust and Division of Asthma, Allergy & Lung Biology, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764) 
7  AstraZeneca, Cambridge, UK (GRID:grid.417815.e) (ISNI:0000 0004 5929 4381) 
8  Observational and Pragmatic Research Institute, Midview City, Singapore (GRID:grid.500407.6); University of Aberdeen, Centre of Academic Primary Care, Division of Applied Health Sciences, Aberdeen, UK (GRID:grid.7107.1) (ISNI:0000 0004 1936 7291) 
Pages
9
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20551010
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41533-023-00331-0
ProQuest document ID
2782558076
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.