Abstract
Osteosarcoma (OS) is the most common primary solid malignant tumour of bone, with rapid progression and a very poor prognosis. Iron is an essential nutrient that makes it an important player in cellular activities due to its inherent ability to exchange electrons, and its metabolic abnormalities are associated with a variety of diseases. The body tightly regulates iron content at the systemic and cellular levels through various mechanisms to prevent iron deficiency and overload from damaging the body. OS cells regulate various mechanisms to increase the intracellular iron concentration to accelerate proliferation, and some studies have revealed the hidden link between iron metabolism and the occurrence and development of OS. This article briefly describes the process of normal iron metabolism, and focuses on the research progress of abnormal iron metabolism in OS from the systemic and cellular levels.
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Details
1 National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Orthopedics, Beijing, People’s Republic of China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839); The Fourth Hospital of Hebei Medical University, Department of Orthopedics, Shijiazhuang, People’s Republic of China (GRID:grid.452582.c)
2 The Fourth Hospital of Hebei Medical University, Department of Orthopedics, Shijiazhuang, People’s Republic of China (GRID:grid.452582.c)
3 National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Orthopedics, Beijing, People’s Republic of China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839)