Serum Lipid Profile and Inflammatory Status in Women with Gestational Diabetes Mellitus

Abstract

Objective:

Gestational diabetes mellitus (GDM) is associated with increased risk of postpartum type 2 diabetes mellitus and cardiovascular risk factors such as obesity, hypertension, dyslipidemia, and systemic inflammation. We aimed to evaluate the lipid profile and inflammatory status assessed by high sensitive C-reactive protein (hsCRP) and TNF-α levels. We also evaluated insulin resistance for all participants.

Methods:

This study was performed including the pregnant with normal glucose challenge test (GCT) and normal glucose tolerance (NGT) (n:20), abnormal GCT and NGT (n:27), and GDM (n:29) defined by Carpenter and Coustan criteria.

Results:

In our study, we could not find significantly differences by means of hsCRP levels and lipid profile parameters between groups. But, TNF-α levels increased significantly in the GDM or abnormal GCT NGT groups as compared to the normal GCT NGT group. hsCRP was correlated independently with LDL-cholesterol and parity in the abnormal GCT NGT group and atherogenic index of the plasma (AIP) in GDM group. In addition, there was not an independent relationship between AIP and hsCRP in the GDM group when multiple linear regression analysis was performed after adjustment for maternal age was evaluated at 29.49 years.

Conclusion:

In conclusion, gestational insulin resistance was apparently associated with TNF-α, whereas dyslipidemia was slightly associated with hsCRP because of the possible effects of maternal age on lipid markers.