Abstract
Cardiac platypnoea-orthodeoxia syndrome (POS) is a position-dependent condition of dyspnoea and hypoxaemia due to right-to-left shunting. It often remains unrecognised in clinical practice, possibly because of its complex underlying pathophysiology. We present four consecutive patients with POS and patent foramen ovale (PFO) who underwent a successful percutaneous PFO closure, describe the mechanism of their POS and provide a review of the literature.
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1 Academic Medical Center—University of Amsterdam, Department of Cardiology, Cardiac Catheterization Laboratory, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431)
2 VU University Medical Center, Department of Cardiology, Amsterdam, The Netherlands (GRID:grid.16872.3a) (ISNI:000000040435165X)
3 VU University Medical Center, Department of Pulmonary Medicine, Amsterdam, The Netherlands (GRID:grid.16872.3a) (ISNI:000000040435165X)
4 Academic Medical Center—University of Amsterdam, Department of Cardiology, Cardiac Catheterization Laboratory, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431); Academic Medical Center, Department of Pediatric Cardiology, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431)
5 Academic Medical Center—University of Amsterdam, Department of Cardiology, Cardiac Catheterization Laboratory, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431); Academic Medical Center, Department of Pediatric Cardiology, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431); Leiden University Medical Center, Department of Pediatric Cardiology, Leiden, The Netherlands (GRID:grid.10419.3d) (ISNI:0000000089452978)
6 Academic Medical Center, Department of Pediatric Cardiology, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431)
7 Academic Medical Center, Department of Cardiothoracic Surgery, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431); Leiden University Medical Center, Department of Pediatric Cardiac Surgery, Leiden, The Netherlands (GRID:grid.10419.3d) (ISNI:0000000089452978)
8 Academic Medical Center—University of Amsterdam, Department of Cardiology, Cardiac Catheterization Laboratory, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431); Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (GRID:grid.411737.7)