Abstract
[...]a total of 6910 non-pregnant participants aged ≥20 years who fasted before attending a morning exam session were selected. [...]a total of 3995 participants were included in the analysis [Supplementary Figure 1, http://links.lww.com/CM9/B363]. Subgroup analysis revealed that participants without diabetes were more inclined to exhibit a negative association between serum total folate and NAFLD [Supplementary Table 2, http://links.lww.com/CM9/B363]. Serum total folate 5-MTHF UMFA Models OR (95% CI) Ptrend OR (95% CI) Ptrend OR (95% CI) Ptrend Model 1 <0.001 <0.001 0.217 Q1 1 (reference) 1 (reference) 1 (reference) Q2 0.70 (0.57–0.87) 0.66 (0.52–0.84) 0.94 (0.72–1.24) Q3 0.67 (0.53–0.84) 0.63 (0.50–0.79) 0.92 (0.72–1.18) Q4 0.37 (0.28–0.49) 0.37 (0.28–0.48) 0.84 (0.63–1.12) Model 2 <0.001 <0.001 0.127 Q1 1 (reference) 1 (reference) 1 (reference) Q2 0.64 (0.49–0.85) 0.62 (0.47–0.83) 0.98 (0.73–1.31) Q3 0.77 (0.56–1.07) 0.75 (0.54–1.02) 0.86 (0.65–1.15) Q4 0.48 (0.35–0.67) 0.49 (0.36–0.67) 0.77 (0.55–1.08) Model 3 <0.001 <0.001 0.034 Q1 1 (reference) 1 (reference) 1 (reference) Q2 0.68 (0.49–0.94) 0.63 (0.46–0.85) 1.08 (0.77–1.51) Q3 0.75 (0.51–1.10) 0.71 (0.50–1.01) 0.85 (0.60–1.22) Q4 0.40 (0.28–0.57) 0.39 (0.28–0.55) 0.70 (0.48–1.03) Model 1 was adjusted for demographic and socioeconomic factors (age, gender, race/ethnicity, family income to poverty ratio, education levels, and marital status).
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1 Department of Gastroenterology, Haining Branch, The First Affiliated Hospital, Zhejiang University School of Medicine, Haining, Zhejiang 314400, China; Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
2 Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
3 Department of Gastroenterology, Haining Branch, The First Affiliated Hospital, Zhejiang University School of Medicine, Haining, Zhejiang 314400, China; Department of Gastroenterology, Haining People's Hospital, Haining, Zhejiang 314400, China; Zhejiang Provincial Clinical Research Center for Digestive Diseases, Hangzhou, Zhejiang 310003, China
4 Department of Gastroenterology, Haining Branch, The First Affiliated Hospital, Zhejiang University School of Medicine, Haining, Zhejiang 314400, China; Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China; Zhejiang Provincial Clinical Research Center for Digestive Diseases, Hangzhou, Zhejiang 310003, China