Abstract
Background
TB and HIV form a deadly synergy in much of the developing world, especially Africa. Interventions to reduce the impact of these diseases at community level are urgently needed. This paper presents the design of a community randomised trial to evaluate the impact of two complex interventions on the prevalence of tuberculosis (TB) in high HIV prevalence settings in Zambia and South Africa.
Methods
The interaction between TB and HIV is reviewed and possible interventions that could reduce the prevalence of TB in HIV-endemic populations are discussed. Two of these interventions are described in detail and the design of a 2 × 2 factorial community randomised trial to test these interventions is presented. The limitations and challenges of the design are identified and discussed.
Conclusion
There is an urgent need to reduce the prevalence of TB in communities highly affected by HIV. Potential interventions are complex and require innovative trial designs to provide the rigorous evidence needed to inform health policy makers and to ensure that resources are used optimally.
Trial Registration
Number: ISRCTN36729271
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 London School of Hygiene & Tropical Medicine, Department of Infectious and Tropical Diseases, London, UK (GRID:grid.8991.9) (ISNI:000000040425469X); University of Zambia, ZAMBART Project, Lusaka, Africa, Zambia (GRID:grid.12984.36) (ISNI:0000000089145257)
2 London School of Hygiene & Tropical Medicine, Department of Epidemiology and Population Health, London, UK (GRID:grid.8991.9) (ISNI:000000040425469X)
3 Stellenbosch University, Desmond Tutu TB Centre, Tygerberg, South Africa (GRID:grid.11956.3a) (ISNI:000000012214904X)
4 London School of Hygiene & Tropical Medicine, Department of Infectious and Tropical Diseases, London, UK (GRID:grid.8991.9) (ISNI:000000040425469X)