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SUMMARY
Objectives: Although clinical research is still going on to determine any relationship between vitamin D and sleep regulation, only few studies have identified the role of vitamin D metabolism in sleep disorders. The current study aims to examine the incidence of vitamin D deficiency/insufficiency in the sample group and its effects on sleep quality and melatonin level. Methods: A cross-sectional study was designed. A total of 79 women aged 18-49 years who applied to the research and training hospital between 1 October and 30 November 2021 participated in the study. Data were collected using a socio-demographic questionnaire prepared by the authors and the Pittsburgh Sleep Quality Index (PSQI). Blood samples were taken from the participants, also, 25-OH-vitamin D3 and melatonin levels in serum samples were measured by ELISA. Results: The participants (n = 79) were aged 29.61 ± 11.14 years. The mean total PSQI scores of the participants were calculated as 5.77 ± 2.70. We determined that 64.6% of the participants had vitamin D deficiency, 21.5% had vitamin D insufficiency, and 13.9% of the participants were vitamin D sufficient. The mean melatonin level was found to be 24.77 ± 27.77 ng/L. We determined that an increase in the melatonin levels decreases the risk of vitamin D deficiency. Besides, our findings showed a good positive correlation between serum melatonin and 25 OH vitamin D3 levels (r=0.544, p < 0.001). Conclusion: Our results indicate that the correction of vitamin D insufficiency can positively affect melatonin levels, therefore, it may positively contribute to the treatment of sleep disorders related to melatonin deficiency.
Key words: vitamin D deficiency, melatonin, sleep quality, woman
Address for correspondence: Z. İ. Sonkaya, Department of Health Care, Sabuncuoǧlu Serefeddin Health Services Vocational School, Amasya University, 05100, Amasya, Turkey. E-mail: [email protected]
INTRODUCTION
It is known that vitamin D has an important role in the endocrine system, calcium homeostasis, and bone metabolism. However, evidence over the last twenty years has indicated that vitamin D is also effective on very divergent biological functions such as induction of cell differentiation, inhibition and immunomodulation of cell growth, and control of other hormonal systems (1). Groups at particular risk are pregnant women, non-white people (black people, Hispanics, or individuals with increased skin melanin pigmentation), obese children and adults,...