Abstract

Background

Intra-arterial chemotherapy has shown promising results and improved the prognosis of retinoblastoma in the developed countries. Here, we aim to report our initial experience, in Egypt, in the treatment of all stages of naïve retinoblastoma with ophthalmic artery chemosurgery (OAC), using melphalan.

Results

The technique was successful in 23 out of 26 eyes. Overall, a total of 63 treatment sessions were performed. Ophthalmic artery catheterization was performed in 59 treatment sessions, whereas middle meningeal artery catheterization was performed in 4 treatment sessions. Adequate tumor control was achieved in 95.6%. Progression has developed in one eye after the third OAC session. The mean follow-up period was 18.5 months. Recurrence of the main tumor as well as vitreous and subretinal seeds was reported in one eye after 19-month duration. A globe salvage rate of 91.3% was attained. No metastasis was recorded, and all patients were alive within the stated follow-up period.

Conclusion

A high globe salvage rate along with metastasis free survival and mild complications were achieved. Therefore, our initial experience with OAC in primary retinoblastoma proved to be safe and effective.

Details

Title
Ophthalmic artery chemosurgery for retinoblastoma: an initial 3-year experience from two major institutes in Egypt
Author
Othman, Moustafa H 1 ; Hassan, Farouk 2 ; Ibrahim, Hamdy M 1 ; Ahmed, Eman Aboelhamd 1 ; Yassa, George 2 ; Abdel-Rahman, Mohamed S 3 ; Rateb, Mahmoud F. 3 ; Riad, Khaled F 4 ; Kamaleldeen, Eman B 5 ; Mohamed, Mohamed Abou Bakr 5 ; Hassan, Shimaa Abbas 6 ; Thabet, Amr M 6 ; Elsawy, Saied Metwaly 6 ; Hamed, Rasha Ahmed 6 ; Imbaby, Ahmed Said 6 ; Soliman, Radwa Kamel 1   VIAFID ORCID Logo 

1  Assiut University, Department of Diagnostic and interventional Radiology, Assiut University Hospitals, Faculty of Medicine, Assiut, Egypt (GRID:grid.252487.e) (ISNI:0000 0000 8632 679X) 
2  Cairo University, Department of Diagnostic and interventional Radiology, Faculty of Medicine, Cairo, Egypt (GRID:grid.7776.1) (ISNI:0000 0004 0639 9286) 
3  Assiut University Hospitals, Department of Ophthalmology, Faculty of Medicine, Assiut, Egypt (GRID:grid.411437.4) (ISNI:0000 0004 0621 6144) 
4  Assiut University, Department of Pediatric Oncology, South Egypt cancer Institute, Assiut, Egypt (GRID:grid.252487.e) (ISNI:0000 0000 8632 679X) 
5  Assiut University Hospitals, Department of Pediatrics, Faculty of Medicine, Assiut, Egypt (GRID:grid.411437.4) (ISNI:0000 0004 0621 6144) 
6  Assiut University Hospitals, Department of Anesthesia and Intensive care,Faculty of Medicine, Assiut, Egypt (GRID:grid.411437.4) (ISNI:0000 0004 0621 6144) 
Pages
79
Publication year
2020
Publication date
Dec 2020
Publisher
Springer Nature B.V.
ISSN
0378603X
e-ISSN
20904762
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43055-020-00200-7
ProQuest document ID
2812739234
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.