Abstract

Background

In the Lake Victoria Basin of western Kenya, malaria remains highly endemic despite high coverage of interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective effect of LLINs is hampered by insecticide resistance in Anopheles vectors and its repurposing by the community. Ceiling nets and LLIN with synergist piperonyl butoxide (PBO-LLIN) are novel tools that can overcome the problems of behavioral variation of net use and metabolic resistance to insecticide, respectively. The two have been shown to reduce malaria prevalence when used independently. Integration of these two tools (i.e., ceiling nets made with PBO-LLIN or Olyset®Plus ceiling nets) appears promising in further reducing the malaria burden.

Methods

A cluster-randomized controlled trial is designed to assess the effect of Olyset®Plus ceiling nets on reducing malaria prevalence in children on Mfangano Island in Homa Bay County, where malaria transmission is moderate. Olyset®Plus ceiling nets will be installed in 1315 residential structures. Malaria parasitological, entomological, and serological indicators will be measured for 12 months to compare the effectiveness of this new intervention against conventional LLIN in the control arm.

Discussion

Wider adoption of Olyset®Plus ceiling nets to complement existing interventions may benefit other malaria-endemic counties and be incorporated as part of Kenya’s national malaria elimination strategy.

Trial registration

UMIN Clinical Trials Registry UMIN000045079. Registered on 4 August 2021.

Details

Title
Evaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial
Author
Kagaya, Wataru 1   VIAFID ORCID Logo  ; Chan, Chim W. 1 ; Kongere, James 1 ; Kanoi, Bernard N. 2 ; Ngara, Mtakai 3 ; Omondi, Protus 4 ; Osborne, Ashley 5 ; Barbieri, Laura 6 ; Kc, Achyut 7 ; Minakawa, Noboru 8 ; Gitaka, Jesse 2 ; Kaneko, Akira 9 

1  Osaka Metropolitan University, Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka, Japan 
2  Mount Kenya University, Directorate of Research and Innovation, Thika, Kenya (GRID:grid.449177.8) (ISNI:0000 0004 1755 2784) 
3  Mount Kenya University, Directorate of Research and Innovation, Thika, Kenya (GRID:grid.449177.8) (ISNI:0000 0004 1755 2784); Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626) 
4  Osaka Metropolitan University, Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka, Japan (GRID:grid.4714.6) 
5  London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, UK (GRID:grid.8991.9) (ISNI:0000 0004 0425 469X) 
6  Osaka Metropolitan University, Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka, Japan (GRID:grid.8991.9) 
7  Osaka Metropolitan University, Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka, Japan (GRID:grid.8991.9); Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626) 
8  Nagasaki University, Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki, Japan (GRID:grid.174567.6) (ISNI:0000 0000 8902 2273) 
9  Osaka Metropolitan University, Department of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka, Japan (GRID:grid.449177.8); Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626); Nagasaki University, Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki, Japan (GRID:grid.174567.6) (ISNI:0000 0000 8902 2273) 
Pages
354
Publication year
2023
Publication date
Dec 2023
Publisher
Springer Nature B.V.
e-ISSN
17456215
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13063-023-07372-3
ProQuest document ID
2819157679
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.