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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Low-density lipoprotein cholesterol (LDL-c) is a direct cause in the development of atherosclerotic cardiovascular disease (ASCVD) [5]. [...]high-density lipoprotein (HDL)-c-raising therapies did not improve patients’ clinical outcomes [11,12,13,14] This is despite evidence from epidemiological studies supporting the role of HDL-c in the development of atherosclerosis [15,16]. [...]patients who received intracoronary tirofiban, a reversible inhibitor of GPIIbIIIa, sustained a smaller infarct size when compared to placebo [41]. The heterogeneity of atherosclerotic disease features, alongside the variations in individuals’ responses to currently available therapies, dictates a more comprehensive approach to understand and quantify the subject’s residual risk. [...]characterizing atherosclerotic disease and matching its features to targeted therapies may offer an opportunity to achieve more accurate intervention, a step closer toward precision medicine.

Details

Title
Advances in Cardiovascular Pharmacology in Atherosclerotic-Related Therapeutic Areas: Addressing Patients’ Clinical Needs
Author
Omari, Muntaser 1   VIAFID ORCID Logo  ; Alkhalil, Mohammad 2   VIAFID ORCID Logo 

 Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK; [email protected] 
 Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK; [email protected]; Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK 
First page
3665
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2824012240
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.