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© 2023 Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:  http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction

Neuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity and inconsistency across these findings, presumably because of the diversity of the disorders themselves, small sample sizes, and site and parameter differences in MRI scanners, and their overall pathogenesis remains unclear. To address these gaps in the literature, we will apply the travelling-subject approach to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. In addition, we will investigate the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioural and psychological measures.

Methods and analysis

We will collect resting-state functional MRI (fMRI) and T1-weighted and diffusion-weighted MRI data from 15 healthy adults as travelling subjects and 300 children (ADHD, n=100; ASD, n=100; and typical development, n=100) with multi-dimensional assessments. We will also apply data from more than 1000 samples acquired in our previous neuroimaging studies on ADHD and ASD.

Ethics and dissemination

The study protocol has been approved by the Research Ethics Committee of the University of Fukui Hospital (approval no: 20220601). Our study findings will be submitted to scientific peer-reviewed journals and conferences.

Details

Title
Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach
Author
Yamashita, Masatoshi 1 ; Kagitani-Shimono, Kuriko 2 ; Hirano, Yoshiyuki 3   VIAFID ORCID Logo  ; Hamatani, Sayo 4 ; Nishitani, Shota 1 ; Yao, Akiko 5 ; Kurata, Sawa 6 ; Kosaka, Hirotaka 7 ; Jung, Minyoung 8 ; Yoshida, Tokiko 9 ; Sasaki, Tsuyoshi 10 ; Matsumoto, Koji 11 ; Kato, Yoko 12 ; Nakanishi, Mariko 2 ; Tachibana, Masaya 2 ; Mohri, Ikuko 2 ; Tsuchiya, Kenji J 13 ; Tsujikawa, Tetsuya 14 ; Okazawa, Hidehiko 15 ; Shimizu, Eiji 3 ; Taniike, Masako 2 ; Tomoda, Akemi 6 ; Mizuno, Yoshifumi 6   VIAFID ORCID Logo 

 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan 
 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan; Molecular Research Centre for Children’s Mental Development, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Paediatrics, Osaka University Graduate School of Medicine, Osaka, Japan 
 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan; Research Centre for Child Mental Development, Chiba University, Chiba, Japan 
 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan; Research Centre for Child Mental Development, Chiba University, Chiba, Japan; Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, Japan 
 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan 
 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan; Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, Japan 
 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan; Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan 
 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan; Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Cognitive Science Research Group, Korea Brain Research Institute, Daegu, Korea (the Republic of) 
 Research Centre for Child Mental Development, Chiba University, Chiba, Japan 
10  Department of Child Psychiatry and Psychiatry, Chiba University Hospital, Chiba, Japan 
11  Department of Radiology, Chiba University Hospital, Chiba, Japan 
12  Department of Paediatrics, Osaka University Graduate School of Medicine, Osaka, Japan 
13  United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan; Research Centre for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan 
14  Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan 
15  Biomedical Imaging Research Centre, University of Fukui, Fukui, Japan 
First page
e070157
Section
Mental health
Publication year
2023
Publication date
2023
Publisher
BMJ Publishing Group LTD
e-ISSN
20446055
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2829003679
Copyright
© 2023 Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:  http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.