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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background and Objectives: To compare autonomic and vascular responses during reactive hyperemia (RH) between healthy individuals and patients with sickle cell anemia (SCA). Materials and Methods: Eighteen healthy subjects and 24 SCA patients were subjected to arterial occlusion for 3 min at the lower right limb level. The pulse rate variability (PRV) and pulse wave amplitude were measured through photoplethysmography using the Angiodin® PD 3000 device, which was placed on the first finger of the lower right limb 2 min before (Basal) and 2 min after the occlusion. Pulse peak intervals were analyzed using time–frequency (wavelet transform) methods for high-frequency (HF: 0.15–0.4) and low-frequency (LF: 0.04–0.15) bands, and the LF/HF ratio was calculated. Results: The pulse wave amplitude was higher in healthy subjects compared to SCA patients, at both baseline and post-occlusion (p < 0.05). Time–frequency analysis showed that the LF/HF peak in response to the post-occlusion RH test was reached earlier in healthy subjects compared to SCA patients. Conclusions: Vasodilatory function, as measured by PPG, was lower in SCA patients compared to healthy subjects. Moreover, a cardiovascular autonomic imbalance was present in SCA patients with high sympathetic and low parasympathetic activity in the basal state and a poor response of the sympathetic nervous system to RH. Early cardiovascular sympathetic activation (10 s) and vasodilatory function in response to RH were impaired in SCA patients.

Details

Title
Autonomic and Vascular Responses during Reactive Hyperemia in Healthy Individuals and Patients with Sickle Cell Anemia
Author
López-Galán, Erislandis 1   VIAFID ORCID Logo  ; Vitón-Castillo, Adrián Alejandro 2   VIAFID ORCID Logo  ; Carrazana-Escalona, Ramón 3 ; Planas-Rodriguez, Maylet 1 ; Adolfo Arsenio Fernández-García 4 ; Cutiño-Clavel, Ileana 1 ; Pascau-Simon, Alexander 5 ; Connes, Philippe 6   VIAFID ORCID Logo  ; Sánchez-Hechavarría, Miguel Enrique 7   VIAFID ORCID Logo  ; Muñoz-Bustos, Gustavo Alejandro 8   VIAFID ORCID Logo 

 Departamento de Ciencias Básicas Biomédicas, Facultad de Medicina, Universidad de Ciencias Médicas de Santiago de Cuba, Santiago de Cuba 90100, Cuba[email protected] (M.P.-R.); [email protected] (I.C.-C.) 
 Facultad de Ciencias Médicas “Dr. Ernesto Che Guevara de la Serna”, Universidad de Ciencias Médicas de Pinar del Rio, Pinar del Rio 20100, Cuba; [email protected] 
 Departamento de Ciencias Clínicas Básicas, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile 
 Facultad de Ciencias Naturales y Exactas, Universidad de Oriente, Santiago de Cuba 90100, Cuba; [email protected] 
 Hospital General “Dr. Juan Bruno Zayas Alfonso”, Laboratorio Vascular no Invasivo, Santiago de Cuba 90400, Cuba; [email protected] 
 LIBM Laboratory, Team “Vascular Biology and Red Blood Cell”, Claude Bernard University Lyon 1, 69622 Lyon, France 
 Grupo Bio-Bio Complejidad, Departamento de Ciencias Clínicas y Preclínicas, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile; Núcleo Científico de Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Adventista de Chile, Chillán 3780000, Chile 
 Facultad de Ciencias de la Salud, Sede Concepción, Universidad de las Américas, Concepcion 4030000, Chile 
First page
1141
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
1010660X
e-ISSN
16489144
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2829836518
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.