Abstract

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer’s disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.

Details

Title
The NLRP3 inflammasome: contributions to inflammation-related diseases
Author
Chen, Ying 1 ; Ye, Xingyan 2 ; Escames, Germaine 3 ; Lei, Wangrui 2 ; Zhang, Xin 4 ; Li, Meng 4 ; Jing, Tong 4 ; Yao, Yu 2 ; Qiu, Zhenye 2 ; Wang, Zheng 5 ; Acuña-Castroviejo, Darío 3 ; Yang, Yang 2   VIAFID ORCID Logo 

1  The First Affiliated Hospital of Xi’an Jiaotong University, Department of Hematology, Xi’an, China (GRID:grid.452438.c) (ISNI:0000 0004 1760 8119) 
2  Northwest University, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Xi’an, China (GRID:grid.412262.1) (ISNI:0000 0004 1761 5538); Xi’an No. 3 Hospital, The Affiliated Hospital of Northwest University, Department of Neurology, Xi’an, China (GRID:grid.412262.1) (ISNI:0000 0004 1761 5538) 
3  University of Granada, Biomedical Research Center, Health Sciences Technology Park, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Ibs. Granada and CIBERfes, Granada, Spain (GRID:grid.507088.2); UGC of Clinical Laboratories, University San Cecilio’s Hospital, Granada, Spain (GRID:grid.507088.2) 
4  Affiliated Hospital, Yan’an University, Department of Cardiology, Yan’an, China (GRID:grid.440747.4) (ISNI:0000 0001 0473 0092) 
5  Central Theater Command General Hospital of Chinese People’s Liberation Army, Department of Cardiothoracic Surgery, Wuhan, China (GRID:grid.414252.4) (ISNI:0000 0004 1761 8894) 
Pages
51
Publication year
2023
Publication date
Dec 2023
Publisher
Springer Nature B.V.
ISSN
1425-8153
e-ISSN
1689-1392
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s11658-023-00462-9
ProQuest document ID
2829995254
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.