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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Metal-organic frameworks (MOFs) have proven to be very effective carriers for drug delivery in various biological applications. In recent years, the development of hybrid nanostructures has made significant progress, including developing an innovative MOF-loaded nanocomposite with a highly porous structure and low toxicity that can be used to fabricate core-shell nanocomposites by combining complementary materials. This review study discusses using MOF materials in cancer treatment, imaging, and antibacterial effects, focusing on oral cancer cells. For patients with oral cancer, we offer a regular program for accurately designing and producing various anticancer and antibacterial agents to achieve maximum effectiveness and the lowest side effects. Also, we want to ensure that the anticancer agent works optimally and has as few side effects as possible before it is tested in vitro and in vivo. It is also essential that new anticancer drugs for cancer treatment are tested for efficacy and safety before they go into further research.

Details

Title
Innovative Metal-Organic Frameworks for Targeted Oral Cancer Therapy: A Review
Author
Mousavi, Seyyed Mojtaba 1 ; Seyyed Alireza Hashemi 2   VIAFID ORCID Logo  ; Fatemeh Fallahi Nezhad 3 ; Binazadeh, Mojtaba 4   VIAFID ORCID Logo  ; Dehdashtijahromi, Milad 4 ; Omidifar, Navid 5 ; Ghahramani, Yasamin 6 ; Chin Wei Lai 7   VIAFID ORCID Logo  ; Wei-Hung, Chiang 1   VIAFID ORCID Logo  ; Gholami, Ahmad 3   VIAFID ORCID Logo 

 Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan; [email protected] 
 Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada; [email protected] 
 Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran; [email protected] 
 Department of Chemical Engineering, School of Chemical and Petroleum Engineering, Shiraz 71557-13876, Iran; [email protected] (M.B.); [email protected] (M.D.) 
 Department of Pathology, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran; [email protected] 
 Associate Professor of Endodontics Department of Endodontics, School of Dentistry Oral and Dental Disease Research Center Shiraz University of Medical Sciences, Shiraz 71956-15787, Iran; [email protected] 
 Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya (UM), Kuala Lumpur 50603, Malaysia 
First page
4685
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
19961944
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2836471965
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.