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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-Lymphocyte Ratio (NLR) serves as a possible biomarker for ongoing inflammatory risks. A total of 720 adults aged 50 years or older from the community-based I-Lan Longitudinal Aging Study were included in this study. General linear regression and ordinally logistic regression analyses were performed to evaluate the association between NLR and CSVD. We further examined the presence of lacune, microbleed, and white matter hyperintensity (WMH) on brain MRI, which were used to construct a combined CSVD score. The NLR was positively associated with WMH (adjusted r = 0.109, p = 0.003), microbleed (adjusted r = 0.102, p = 0.006), and lacune (adjusted r = 0.100, p = 0.008). After adjustments for smoking, drinking, and physical activity in the ordinal logistic regression analysis, age, gender, brachial Systolic Blood Pressure (SBP), fasting glucose, LDL-cholesterol, and Hs-CRP were compared among subjects with low tertile (T1), medium tertile (T2) and high tertile (T3) NLR. The results showed that T2 vs. T1 had an odds ratio of 1.23 (0.86–1.77); and T3 vs. T1 had an odds ratio of 1.87 (1.29–2.71) of CSVD scores in four groups (zero (reference group), one, two, and three or more). NLR could be used to assess the state of inflammation in cerebral vessels. A significant and positive correlation between NLR and CSVD was verified in this study. However, the practical clinical application of NLR in CSVD patients and prognosis prediction should be validated through more scientific attempts.

Details

Title
Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study
Author
Shao-Yuan, Chuang 1 ; Yin-Chen, Hsu 2 ; Kuang-Wei Chou 3   VIAFID ORCID Logo  ; Kuo-Song, Chang 4 ; Wong, Chiong-Hee 5 ; Hsu, Ya-Hui 3 ; Hao-Min, Cheng 6 ; Chien-Wei, Chen 7   VIAFID ORCID Logo  ; Pang-Yen, Chen 8   VIAFID ORCID Logo 

 Institute of Population Health Science, National Health Research Institute, Miaoli 36001, Taiwan; Institute of Public Health, National Yang Ming Chiao Tung University School of Medicine, Taipei 30010, Taiwan 
 Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan; Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi 61363, Taiwan; College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan 
 Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan; Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 11008, Taiwan 
 Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 11008, Taiwan; Mackay Junior College of Medicine, Nursing, and Management, Taipei 11260, Taiwan 
 Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 11008, Taiwan 
 Institute of Public Health, National Yang Ming Chiao Tung University School of Medicine, Taipei 30010, Taiwan; Department of Internal Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei 31254, Taiwan; Center for Evidence-Based Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan; Department of Medical Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan 
 Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi 61363, Taiwan; College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan 
 Institute of Public Health, National Yang Ming Chiao Tung University School of Medicine, Taipei 30010, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan; Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 11008, Taiwan 
First page
1087
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20763425
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2843032063
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.