Abstract

Nowadays, treatment of metastatic breast cancer (MBC) has been enriched with novel therapeutical strategies. Metronomic chemotherapy (mCHT) is a continuous and frequent administration of chemotherapy at a lower dose and so whit less toxicity. Thus, this strategy could be attractive for elderly MBC patients. Aim of this analysis is to provide insights into mCHT’s activity in a real-life setting of elderly MBC patients. Data of patients ≥ 75 years old included in VICTOR-6 study were analyzed. VICTOR-6 is a multicentre, Italian, retrospective study, which collected data on mCHT in MBC patients treated between 2011 and 2016. A total of 112 patients were included. At the beginning of mCHT, median age was 81 years (75–98) and in 33% of the patients mCHT was the first line choice. Overall Response Rate (ORR) and Disease Control Rate (DCR) were 27.9% and 79.3%, respectively. Median PFS ranged between 7.6 and 9.1 months, OS between 14.1 and 18.5 months. The most relevant toxicity was the hematological one (24.1%); severe toxicity (grade 3–4) ranged from 0.9% for skin toxicity up to 8% for hematologic one. This is a large study about mCHT in elderly MBC patients, providing insights to be further investigated in this subgroup of frail patients.

Details

Title
Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients
Author
Trevisan, B. 1 ; Pepe, F. F. 1 ; Vallini, I. 2 ; Montagna, E. 3 ; Amoroso, D. 4 ; Berardi, R. 5 ; Butera, A. 6 ; Cagossi, K. 7 ; Cavanna, L. 8 ; Ciccarese, M. 9 ; Cinieri, S. 10 ; Cretella, E. 11 ; De Conciliis, E. 12 ; Febbraro, A. 13 ; Ferraù, F. 14 ; Ferzi, A. 15 ; Baldelli, A. 16 ; Fontana, A. 17 ; Gambaro, A. R. 18 ; Garrone, O. 19 ; Gebbia, V. 20 ; Generali, D. 21 ; Gianni, L. 22 ; Giovanardi, F. 23 ; Grassadonia, A. 24 ; Leonardi, V. 25 ; Sarti, S. 26 ; Musolino, A. 27 ; Nicolini, M. 22 ; Putzu, C. 28 ; Riccardi, F. 29 ; Santini, D. 30 ; Sarobba, M. G. 31 ; Schintu, M. G. 32 ; Scognamiglio, G. 33 ; Spadaro, P. 34 ; Taverniti, C. 35 ; Toniolo, D. 36 ; Tralongo, P. 37 ; Turletti, A. 38 ; Valenza, R. 39 ; Valerio, M. R. 40 ; Vici, P. 41 ; Clivio, L. 42 ; Torri, V. 42 ; Cazzaniga, M. E. 1 

1  Azienda Ospedaliera San Gerardo, Monza, Italy (GRID:grid.415025.7) (ISNI:0000 0004 1756 8604) 
2  Ospedale di Circolo e Fondazione Macchi, Varese, Italy (GRID:grid.412972.b) (ISNI:0000 0004 1760 7642) 
3  European Institute of Oncology, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843) 
4  Ospedale Versilia, Camaiore, Italy (GRID:grid.459640.a) (ISNI:0000 0004 0625 0318) 
5  Azienda Ospedaliera Universitaria Ospedali Riuniti, Torrette, Italy (GRID:grid.459640.a) 
6  Nuovo Ospedale San Giovanni Di Dio, Florence, Italy (GRID:grid.416649.8) (ISNI:0000 0004 1763 4122) 
7  Ospedale Ramazzini, Carpi, Italy (GRID:grid.416649.8) 
8  Azienda Ospedaliera Piacenza, Piacenza, Italy (GRID:grid.417085.f) 
9  Ospedale Vito Fazzi, Lecce, Italy (GRID:grid.417011.2) (ISNI:0000 0004 1769 6825) 
10  Ospedale A. Perrino, Brindisi, Italy (GRID:grid.417511.7) 
11  Ospedale Bolzano, Bolzano, Italy (GRID:grid.415844.8) (ISNI:0000 0004 1759 7181) 
12  ASL Asti, Asti, Italy (GRID:grid.415844.8) 
13  Ospedale S. Cuore di Gesù Fatebenefratelli, Benevento, Italy (GRID:grid.415844.8) 
14  Ospedale San Vincenzo, Taormina, Italy (GRID:grid.415844.8) 
15  Azienda Ospedaliera Ospedale Civile Di Legnano, Magenta, Italy (GRID:grid.414962.c) (ISNI:0000 0004 1760 0715) 
16  Ospedale San Salvatore, Coppito, Italy (GRID:grid.415103.2) 
17  Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (GRID:grid.144189.1) (ISNI:0000 0004 1756 8209) 
18  ASST Fatebenefratelli Sacco, Milan, Italy (GRID:grid.507997.5) (ISNI:0000 0004 5984 6051) 
19  Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy (GRID:grid.414818.0) (ISNI:0000 0004 1757 8749) 
20  Ospedale La Maddalena, Palermo, Italy (GRID:grid.492805.2) 
21  Istituti Ospitalieri Cremona, Cremona, Italy (GRID:grid.419450.d) 
22  Ospedale Infermi, Rimini, Italy (GRID:grid.414614.2) 
23  AUSL della Romagna, Emilia-Romagna, Italy (GRID:grid.414614.2) 
24  Ospedale SS Annunziata, Taranto, Italy (GRID:grid.420350.0) (ISNI:0000 0004 1794 434X) 
25  Ospedale Civico, Palermo, Italy (GRID:grid.420350.0) 
26  IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy (GRID:grid.419563.c) (ISNI:0000 0004 1755 9177) 
27  Ospedale di Parma, Parma, Italy (GRID:grid.411482.a) 
28  Azienda Ospedaliera-Universitaria, Sassari, Italy (GRID:grid.414614.2) 
29  Ospedale Antonio Cardarelli, Naples, Italy (GRID:grid.413172.2) 
30  Università Campus Bio-Medico, RomE, Italy (GRID:grid.9657.d) (ISNI:0000 0004 1757 5329) 
31  Ospedale San Francesco, Nuoro, Italy (GRID:grid.9657.d) 
32  Ospedale Giovanni Paolo II, Lecce, Italy (GRID:grid.9657.d) 
33  Ospedale Valduce, Como, Italy (GRID:grid.417206.6) (ISNI:0000 0004 1757 9346) 
34  Casa di Cura Villa Salus-Messina, Messina, Italy (GRID:grid.417206.6) 
35  Ospedale Molinette, Turin, Italy (GRID:grid.413005.3) (ISNI:0000 0004 1760 6850) 
36  Ospedale di Circolo, Rho, Italy (GRID:grid.412972.b) (ISNI:0000 0004 1760 7642) 
37  Ospedale Umberto I, Rome, Italy (GRID:grid.411490.9) (ISNI:0000 0004 1759 6306) 
38  Ospedale Martini, Torino, Italy (GRID:grid.416473.3) (ISNI:0000 0004 1763 0797) 
39  P.O. Vittorio Emanuele, Gela, Italy (GRID:grid.416473.3) 
40  A.O.U. Policlinico Paolo Giaccone, Palermo, Italy (GRID:grid.416473.3) 
41  INT Regina Elena, Rome, Italy (GRID:grid.416473.3) 
42  IRCCS Mario Negri Institute of Pharmacological Research, Milan, Italy (GRID:grid.4527.4) (ISNI:0000000106678902) 
Pages
12255
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-023-39386-x
ProQuest document ID
2843248173
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.