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Abstract
Mounting evidence has found that tumor microenvironment (TME) plays an important role in the tumor progression of lung adenocarcinoma (LUAD). However, the roles of tumor microenvironment-related genes in immunotherapy and clinical outcomes remain unclear. In this study, 6 TME-related genes (PLK1, LDHA, FURIN, FSCN1, RAB27B, and MS4A1) were identified to construct the prognostic model. The established risk scores were able to predict outcomes at 1, 3, and 5 years with greater accuracy than previously known models. Moreover, the risk score was closely associated with immune cell infiltration and the immunoregulatory genes including T cell exhaustion markers. In conclusion, the TME risk score can function as an independent prognostic biomarker and a predictor for evaluating immunotherapy response in LUAD patients, which provides recommendations for improving patients’ response to immunotherapy and promoting personalized tumor immunotherapy in the future.
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Details
1 Suining Central Hospital, Department of Oncology, Suining, China
2 The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Molecular Oncology and Epigenetics, Chongqing, China (GRID:grid.452206.7) (ISNI:0000 0004 1758 417X)
3 Suining Central Hospital, Department of Oncology, Suining, China (GRID:grid.452206.7)
4 Suining Central Hospital, Gastrointestinal Surgical Unit, Suining, China (GRID:grid.452206.7)