Abstract

Background: Dengue infection is endemic in Bangladesh and presents with varying degrees of severity of illness in children.

Objective:The purpose of the present study was to assess the common clinical profile, biochemical findings and outcome of severe dengue fever in children.

Methodology: This prospective cohot study was conducted on dengue NS1 or IgM or RT-PCR positive admitted children up to 14 years of age from April 2019 to October 2019 for a period of 6 months at the Pediatrics Department of Evercare Hospital, Dhaka. Data were analyzed after collection of demographic variables, presenting complaints and examination findings of 75 enrolled children.

Results:A total of 75 cases were classified as severe dengue fever. The most common age of presentation was 4 to 7 years. The most common presenting symptom of severe dengue cases were fever (97.3%), abdominal pain and vomiting (77.3%) and shock (62.7%). Pleural effusion was the most common physical findings seen in 35 cases (46.6%) followed by ascites in 26 cases (34.7%). Elevation in aspartate amino transaminase AST (IU/L) was found in 82.6%, low albumin was found in 78.7% of the cases. Hypernatremia was the most common electrolyte abnormality found in 35 cases (46.7%). Regarding coagulation profile, raised D-dimer & low fibrinogen were found in 53 (70.7%) & 42 cases (56.0%) respectively. Activated partial thromboplastin time (aPTT) was prolonged in 37.3%. Case fatality rate (CFR) was 5.3%.

Conclusion: In conclusion, raised AST and D-dimer, low fibrinogen & albumin level as well as hyponatremia are significant laboratory findings indicating severity of the disease. Shock is a common presentation of severe dengue in children.

Details

Title
Clinical Profile, Laboratory Findings and Outcome of Severe Dengue Infection among Children Admitted at a Tertiary Care Hospital in Bangladesh
Author
Ferdous, Jannatul  VIAFID ORCID Logo  ; Hassan, M Quamrul  VIAFID ORCID Logo  ; Sultana, Sabina  VIAFID ORCID Logo  ; Naher, Nurun  VIAFID ORCID Logo  ; Hossain, Mohammed Istiaque  VIAFID ORCID Logo  ; Badrun Nessa  VIAFID ORCID Logo  ; Nahar, Laila Nurun  VIAFID ORCID Logo  ; Nahid, Farzana  VIAFID ORCID Logo 
Pages
40-46
Section
Articles
Publication year
2022
Publication date
2022
Publisher
National Institute of Neurosciences & Hospital
ISSN
24114820
e-ISSN
2411670X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2857810366
Copyright
© 2022. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.