Abstract
Background
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease showing a rising prevalence globally. Genetic predisposition plays a key role in the development and progression of the disease pathogenicity.
Main body
This paper summarizes genetic associations based on their influence on several metabolic aspects such as lipid metabolism, glucose metabolism, hepatic iron accumulation and cholesterol metabolism toward the NAFLD pathogenicity. Furthermore, we present variations in some epigenetic characters and the microRNA profile with regard to NAFLD.
Conclusion
As reported in many studies, the PNPLA3 rs738409 variant seems to be significantly associated with NAFLD susceptibility. Other gene variants like TM6SF2 rs58542926, MBOAT7 rs641738 and GCKR variants also appear to be more prevalent among NAFLD patients. We believe these genetic variants may provide insights into new trends in developing noninvasive biomarkers and identify their suitability in clinical practice in the future.
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Details
1 University of Colombo, Institute of Biochemistry, Molecular Biology and Biotechnology, Colombo 03, Sri Lanka (GRID:grid.8065.b) (ISNI:0000 0001 2182 8067)
2 University of Kelaniya, Department of Surgery, Faculty of Medicine, Ragama, Sri Lanka (GRID:grid.45202.31) (ISNI:0000 0000 8631 5388)
3 University of Kelaniya, Department of Medicine, Faculty of Medicine, Ragama, Sri Lanka (GRID:grid.45202.31) (ISNI:0000 0000 8631 5388)