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© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Coherent anti-Stokes Raman scattering (CARS) generates a strong label-free signal in the long wavenumber C─H stretching region. Lipid-rich myelinated tissues, such as brain and spinal cord, would appear to be ideal subjects for imaging with CARS laser-scanning microscopy. However, the highly ordered, biochemically complex, and highly scattering nature of such tissues complicate the use of the technique. A CARS microscopy approach is presented that overcomes the challenges of imaging myelinated tissue to achieve chemically and orientationally sensitive high-resolution images.

Details

Title
Excitation parameters optimized for coherent anti-Stokes Raman scattering imaging of myelinated tissue
Author
Brideau, Craig; Poon, Kelvin W C; Colarusso, Pina; Stys, Peter K
First page
46502
Section
Microscopy
Publication year
2019
Publication date
Apr 2019
Publisher
S P I E - International Society for
ISSN
1083-3668
e-ISSN
1560-2281
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2859561415
Copyright
© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.