It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
The number of diabetic foot ulcer patients is substantially increasing, with the rapidly rising burden of diabetic mellitus in sub-Saharan Africa. The data on the regional prevalence of diabetic foot ulcer infecting bacteria and their antimicrobial resistance patterns is crucial for its proper management. This systematic review and meta-analysis determined the pooled prevalence of bacterial profiles and antimicrobial resistance patterns of infected diabetic foot ulcers in sub-Saharan Africa. A comprehensive search of the literature was performed on CINAHL, EMBASE, Google Scholar, PubMed, Scopus, and Web of Science databases. Critical appraisal was done using the Joanna Briggs Institute’s tool for prevalence studies. A pooled statistical meta-analysis was conducted using STATA Version 17.0. The I2 statistics and Egger’s test were used to assess the heterogeneity and publication bias. The pooled prevalence and the corresponding 95% confidence interval of bacterial profiles and their antimicrobial resistance patterns were estimated using a random effect model. Eleven studies with a total of 1174 study participants and 1701 bacteria isolates were included. The pooled prevalence of the most common bacterial isolates obtained from DFU were S. aureus (34.34%), E. coli (21.16%), and P. aeruginosa (20.98%). The highest pooled resistance pattern of S. aureus was towards Gentamicin (57.96%) and Ciprofloxacin (52.45%). E.coli and K. Pneumoniae showed more than a 50% resistance rate for the most common antibiotics tested. Both gram-positive and gram-negative bacteria were associated with diabetic foot ulcers in sub-Saharan Africa. Our findings are important for planning treatment with the appropriate antibiotics in the region. The high antimicrobial resistance prevalence rate indicates the need for context-specific effective strategies aimed at infection prevention and evidence-based alternative therapies.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Armauer Hansen Research Institute, Ministry of Health, Addis Ababa, Ethiopia (GRID:grid.418720.8) (ISNI:0000 0000 4319 4715); Wolaita Sodo University, Department of Medical Laboratory, College of Health Sciences, Wolaita Sodo, Ethiopia (GRID:grid.494633.f) (ISNI:0000 0004 4901 9060); Addis Ababa University, Department of Biomedical Sciences, College of Natural and Computational Sciences, Addis Ababa, Ethiopia (GRID:grid.7123.7) (ISNI:0000 0001 1250 5688)
2 Kansas City University, College of Osteopathic Medicine, Kansas City, USA (GRID:grid.258405.e) (ISNI:0000 0004 0539 5056)
3 Wachemo University, Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital (NEMMCSH), Hossana, Ethiopia (GRID:grid.258405.e) (ISNI:0000 0004 4901 9052)
4 Armauer Hansen Research Institute, Ministry of Health, Addis Ababa, Ethiopia (GRID:grid.418720.8) (ISNI:0000 0000 4319 4715); Wolaita Sodo University, Department of Medical Laboratory, College of Health Sciences, Wolaita Sodo, Ethiopia (GRID:grid.494633.f) (ISNI:0000 0004 4901 9060)
5 Jimma University Medical Center, Jimma, Ethiopia (GRID:grid.411903.e) (ISNI:0000 0001 2034 9160)
6 Myungsung Medical Center, Addis Ababa, Ethiopia (GRID:grid.411903.e)
7 Université du Québec en Abitibi-Témiscamingue, World Health Programme, Montreal, Canada (GRID:grid.265704.2) (ISNI:0000 0001 0665 6279); Karolinska Institutet, Department of Global Public Health, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626)
8 Armauer Hansen Research Institute, Ministry of Health, Addis Ababa, Ethiopia (GRID:grid.418720.8) (ISNI:0000 0000 4319 4715)
9 KNCV, USAID Eliminate TB Project, Addis Ababa, Ethiopia (GRID:grid.418720.8)
10 Armauer Hansen Research Institute, Ministry of Health, Addis Ababa, Ethiopia (GRID:grid.418720.8) (ISNI:0000 0000 4319 4715); Jimma University, Ethiopian-Evidence Based Health Care Centre: A JBI Center of Excellence, Public Health Faculty, Institute of Health, Jimma, Ethiopia (GRID:grid.411903.e) (ISNI:0000 0001 2034 9160)