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Abstract
BACKGROUND: Cardiovascular diseases are group of problems that occur when the heart and its blood vessels fail to work. According to WHO, these take the lives of 17.7 million people every year and 31% of all global deaths. Acute Myocardial infarction (121.3) are its most important consequence. It virtually occurs at all ages but incidence is higher in the elderly people and males. Search for new and efficacious drugs to combat this condition is the need of the hour. was taken up. MATERIALS AND METHODS: Aqueous and Ksheerapaka of the trial drugs were used as dosage forms. The study was carried out in Isoproterenol Induced Myocardial necrosis – Rona et al method. The male wistar rats were divided into 7 groups of 6 animals in each and pretreated with the respective doses for the period of 28 days followed by induction of necrosis. The parameters taken to access the results were CK-MB, AST, ALT, LDH, GSH,Total Protein and Histo-pathology. The results were statistically analyzed using one-way ANOVA variance and Tukeys multiple comparison tests. RESULTS: The results of the experimental study reveal that both the trial drugs provide an adequate protection from free radical scavengers and oxidative stress and help them in maintaining the endogenous anti-oxidant levels. They were also contributory in maintaining the structural integrity of the cardiac cells thereby preventing any leakage of enzymes into the serum. DISCUSSION: Hrudya dravyas are congenial to mind and are ideal for heart. Hrudya karma has sub activities like Lekhana, Tarpana, Rasayana, Balya and shonita sanghata bheda. Gokshura being one among Laghupanchamoola is Hrudya; mentioned as Hrudrogahara and Gambahri is Hrudya, Balya, Rasayana, Medhya. Presence of Flavonoids, Glycosides, Tannins, Triterpenoids in both the drugs are responsible for this activity. Cardio protective drugs act in different ways like anti-coagulant, vasodilator, cardiac stimulant etc.
