It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We present genome-wide association studies of short ( ≤ 5 h) and long ( ≥ 10 h) sleep duration in adults of European (N = 445,966), African (N = 27,785), East Asian (N = 3141), and admixed-American (N = 16,250) ancestry from UK Biobank and the Million Veteran Programme. In a cross-population meta-analysis, we identify 84 independent loci for short sleep and 1 for long sleep. We estimate SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identify positive genetic correlation between short and long sleep traits (rg = 0.16 ± 0.04; p = 0.0002), as well as similar patterns of genetic correlation with other psychiatric and cardiometabolic phenotypes. Mendelian randomisation reveals a directional causal relationship between short sleep and depression, and a bidirectional causal relationship between long sleep and depression.
Here, the authors investigate the genetic basis of short ( ≤ 5 h) and long ( ≥ 10 h) sleep duration, identifying 84 independent significant risk loci for short sleep and 1 locus for long sleep, and causal associations between sleep and psychiatric traits.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details












1 University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); King’s College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764)
2 Yale University School of Medicine, Division of Human Genetics, Department of Psychiatry, New Haven, USA (GRID:grid.47100.32) (ISNI:0000 0004 1936 8710); Veterans Affairs Connecticut Healthcare Center, Department of Psychiatry, West Haven, USA (GRID:grid.47100.32)
3 University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); University College London, UCL Genetics Institute, Division of Biosciences, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201)
4 University College London, Health Data Research UK, Institute of Health Informatics, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
5 University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); Icahn School of Medicine at Mount Sinai, Department of Genetics & Genomic Sciences and Department of Pediatrics, New York, USA (GRID:grid.59734.3c) (ISNI:0000 0001 0670 2351)
6 University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201)
7 Yale University, School of Medicine, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710); Food and Drug Administration (FDA), Office of Medical Policy, Center for Drug Evaluation and Research, Silver Spring, USA (GRID:grid.483500.a) (ISNI:0000 0001 2154 2448)
8 University of Pittsburgh, Department of Psychiatry, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
9 VA Boston Healthcare System, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston, USA (GRID:grid.410370.1) (ISNI:0000 0004 4657 1992); Brigham & Women’s Hospital and Harvard Medical School, Department of Medicine, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294)
10 1400 VFW Parkway (111PI), VA Boston Healthcare System, West Roxbury, USA (GRID:grid.410370.1) (ISNI:0000 0004 4657 1992); Brigham & Women’s Hospital, Division of Sleep and Circadian Disorders, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Harvard Medical School, Division of Sleep Medicine, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
11 VA San Diego Healthcare System, Psychiatry Service, San Diego, USA (GRID:grid.410371.0) (ISNI:0000 0004 0419 2708); University of California, San Diego, Departments of Psychiatry and Herbert Wertheim School of Public Health, La Jolla, USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242)
12 University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); University College London, Institute of Cognitive Neuroscience, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)