Abstract

Background/aims

The natural history of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) is still unknown. This retrospective study aims to determine the morphological changes of BD-IPMNs with attention to the history of surgical resection for extrapancreatic malignancies.

Methods and materials

This study included 427 subjects with BD-IPMN at the Osaka Medical College from January 2001 to December 2019; 134 patients were included. The predictive factors for the progression of BD-IPMN based on morphological changes were evaluated by univariate as well as multivariate analyses. Furthermore, the clinical features of BD-IPMNs with progressive lesions during follow-up were investigated.

Results

The average interval of follow-up was 35.8 months (with a range between 12.1 and 157 months). Disease progression occurred in 6 subjects (4.5%). In two of them (1.5%), IPMN-related invasive carcinoma was found. Multivariate analysis demonstrated that surgical resection for extrapancreatic malignancies was a significant predictor of BD-IPMN progression.

Conclusion

The history of resection of extrapancreatic malignancies should be considered during the follow-up of BD-IPMN.

Details

Title
Progression of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) after surgery for extrapancreatic malignancies
Author
Imoto, Akira 1 ; Ogura, Takeshi 1 ; Masuda, Daisuke 1 ; Narabayashi, Ken 1 ; Okada, Toshihiko 1 ; Abe, Yosuke 1 ; Takeuchi, Toshihisa 1 ; Inoue, Takuya 1 ; Ishida, Kumi 1 ; Nouda, Sadaharu 1 ; Higuchi, Kazuhide 1 ; Abdelaal, Usama M. 2   VIAFID ORCID Logo 

1  Osaka Medical College, The 2nd Department of Internal Medicine, Osaka, Japan (GRID:grid.444883.7) (ISNI:0000 0001 2109 9431) 
2  Osaka Medical College, The 2nd Department of Internal Medicine, Osaka, Japan (GRID:grid.444883.7) (ISNI:0000 0001 2109 9431); Sohag University Hospital, Gastroenterology and Hepatology Unit, Internal Medicine Department, Sohag, Egypt (GRID:grid.412659.d) (ISNI:0000 0004 0621 726X) 
Pages
58
Publication year
2023
Publication date
Dec 2023
Publisher
Springer Nature B.V.
ISSN
20906218
e-ISSN
20906226
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43066-023-00286-4
ProQuest document ID
2881545930
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.