Abstract

Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC50 values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.

Details

Title
New halimane and clerodane diterpenoids from Croton cnidophyllus
Author
Wei, Xun 1 ; Huang, Jia-Luo 1 ; Gao, Hua-Hua 1 ; Yuan, Fang-Yu 1 ; Tang, Gui-Hua 1   VIAFID ORCID Logo  ; Yin, Sheng 1 

1  Sun Yat-Sen University, School of Pharmaceutical Sciences, Guangzhou, People’s Republic of China (GRID:grid.12981.33) (ISNI:0000 0001 2360 039X) 
Pages
21
Publication year
2023
Publication date
Dec 2023
Publisher
Springer Nature B.V.
ISSN
21922195
e-ISSN
21922209
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s13659-023-00386-z
ProQuest document ID
2890351671
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.