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© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Endoscopic optical coherence tomography (OCT) is a valuable tool for providing diagnostic images of internal organs and guiding interventions in real time. Miniaturized OCT endoscopes are essential for imaging small and convoluted luminal organs while minimizing invasiveness. However, current methods for fabricating miniature fiber probes have limited ability to correct optical aberrations, leading to suboptimal imaging performance. Here we introduce a liquid shaping technique for the rapid and scalable fabrication of ultrathin and high-performance OCT microendoscopes suitable for minimally invasive clinical applications. This technique enables the flexible customization of freeform microlenses with sub-nanometer optical surface roughness by regulating the minimum energy state of curable optical liquid on a wettability-modified substrate and precisely controlling the liquid volume and physical boundary on a substrate. Using this technique, we simultaneously fabricated 800-nm OCT microendoscopes with a diameter of approximately 0.6 mm and evaluated their ultrahigh-resolution imaging performance in the esophagus of rats and the aorta and brain of mice.

Chao Xu et al. introduce a liquid shaping technique for the rapid and scalable fabrication of ultrathin and high-performance optical coherence tomography microendoscopes, suitable for minimally invasive clinical applications.

Details

Title
Liquid-shaped microlens for scalable production of ultrahigh-resolution optical coherence tomography microendoscope
Author
Xu, Chao 1   VIAFID ORCID Logo  ; Guan, Xin 2 ; Abbasi, Syeda Aimen 1   VIAFID ORCID Logo  ; Xia, Neng 3 ; Ngai, To 2 ; Zhang, Li 3   VIAFID ORCID Logo  ; Ho, Ho-Pui 1 ; Ng, Sze Hang Calvin 4 ; Yuan, Wu 1   VIAFID ORCID Logo 

 The Chinese University of Hong Kong, Department of Biomedical Engineering, Hong Kong SAR, China (GRID:grid.10784.3a) (ISNI:0000 0004 1937 0482) 
 The Chinese University of Hong Kong, Department of Chemistry, Hong Kong SAR, China (GRID:grid.10784.3a) (ISNI:0000 0004 1937 0482) 
 The Chinese University of Hong Kong, Department of Mechanical and Automation Engineering, Hong Kong SAR, China (GRID:grid.10784.3a) (ISNI:0000 0004 1937 0482) 
 The Chinese University of Hong Kong, Department of Surgery, Hong Kong SAR, China (GRID:grid.10784.3a) (ISNI:0000 0004 1937 0482) 
Pages
1
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
e-ISSN
27313395
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2908991767
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.