Abstract

Schiff bases are a diverse group of organic compounds with great pharmaceutical importance due to the presence of carbon–nitrogen double bonds (–C=N–). These compounds are synthesized by the condensation reaction between a primary amine and an aldehyde or ketone in a suitable solvent such as methanol. These compounds have shown antibacterial, antifungal, antiviral, anti-inflammatory, and antioxidant activities, which have garnered the attention of organic chemists in synthesizing these compounds. Recent advances have been summarized in this review paper mainly including compounds with potential antibacterial, antifungal, and antiviral activities. Synthetic schemes are included to provide a better understanding of the Schiff base synthesis mechanism. This review paper will provide a way forward for the pharmaceutical chemist to synthesize new compounds with potential biological activities.

Details

Title
Pharmaceutical significance of Schiff bases: an overview
Author
Mushtaq, Irfan 1   VIAFID ORCID Logo  ; Ahmad, Maqbool 1 ; Saleem, Muhammad 1 ; Ahmed, Adnan 2 

1  Ghazi University, Department of Chemistry, Dera Ghazi Khan, Pakistan (GRID:grid.448869.f) (ISNI:0000 0004 6362 6107) 
2  Gomal University, Institute of Chemical Sciences, Dera Ismail Khan, Pakistan (GRID:grid.411749.e) (ISNI:0000 0001 0221 6962) 
Pages
16
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
ISSN
23147245
e-ISSN
23147253
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43094-024-00594-5
ProQuest document ID
2925318266
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.