Abstract

Targeted delivery of anti-tumor drugs and overcoming drug resistance in malignant tumor cells remain significant clinical challenges. However, there are only few effective methods to address these issues. Extracellular vesicles (EVs), actively secreted by cells, play a crucial role in intercellular information transmission and cargo transportation. Recent studies have demonstrated that engineered EVs can serve as drug delivery carriers and showed promising application prospects. Nevertheless, there is an urgent need for further improvements in the isolation and purification of EVs, surface modification techniques, drug assembly processes, and precise recognition of tumor cells for targeted drug delivery purposes. In this review, we summarize the applications of engineered EVs in cancer treatment and overcoming drug resistance, and current challenges associated with engineered EVs are also discussed. This review aims to provide new insights and potential directions for utilizing engineered EVs as targeted delivery systems for anti-tumor drugs and overcoming drug resistance in the near future.

Details

Title
Engineered extracellular vesicles: A new approach for targeted therapy of tumors and overcoming drug resistance
Author
Ming-Kun, Chen 1   VIAFID ORCID Logo  ; Chen Zi-Xian 1 ; Mao-Ping, Cai 1 ; Chen, Hong 2 ; Zhuang-Fei, Chen 3 ; Shan-Chao, Zhao 4 

1  Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, P. R. China; The Third Clinical College, Southern Medical University, Guangzhou, Guangdong, P. R. China 
2  Luoyang Key Laboratory of Organic Functional Molecules, College of Food and Drug, Luoyang Normal University, Luoyang, Henan, P. R. China 
3  Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China 
4  Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, P. R. China; The Third Clinical College, Southern Medical University, Guangzhou, Guangdong, P. R. China; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China 
Pages
205-225
Section
REVIEWS
Publication year
2024
Publication date
Feb 2024
Publisher
John Wiley & Sons, Inc.
e-ISSN
2523-3548
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1002/cac2.12518
ProQuest document ID
2928277579
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.