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Abstract
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy (RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.
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1 Sichuan University, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Chengdu, China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581)
2 Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Department of Cariology and Endodontology, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319)
3 Shanghai Key Laboratory of Stomatology, Department of Endodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, National Center for Stomatology, Shanghai, China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293)
4 Sun Yat-Sen University & Guangdong Provincial Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, Hospital of Stomatology, Guanghua, School of Stomatology, Guangzhou, China (GRID:grid.452802.9)
5 Wuhan University, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan, China (GRID:grid.49470.3e) (ISNI:0000 0001 2331 6153)
6 The Fourth Military Medical University, Department of Operative Dentistry & Endodontics, School of Stomatology, Xi’an, China (GRID:grid.233520.5) (ISNI:0000 0004 1761 4404)
7 Capital Medical University, Department of Endodontics, Beijing Stomatological Hospital, School of Stomatology, Beijing, China (GRID:grid.24696.3f) (ISNI:0000 0004 0369 153X)
8 Sichuan University, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Preventive Dentistry, West China Hospital of Stomatology, Chengdu, China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581)
9 Sichuan University, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Geriatric dentistry, West China Hospital of Stomatology, Chengdu, China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581)
10 Chinese PLA General Hospital, Department of Stomatology, First Medical Center, Beijing, China (GRID:grid.414252.4) (ISNI:0000 0004 1761 8894)
11 China Medical University, Department of Endodontics, School of Stomatology, Shenyang, China (GRID:grid.254145.3) (ISNI:0000 0001 0083 6092)
12 Guangxi Medical University, College of Stomatology, Hospital of Stomatology, Nanning, China (GRID:grid.256607.0) (ISNI:0000 0004 1798 2653)
13 Nanjing Medical University, Department of Endodontics, School and Hospital of Stomatology, Nanjing, China (GRID:grid.89957.3a) (ISNI:0000 0000 9255 8984)
14 Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Endodontics, Stomatological Hospital and Dental School of Tongji University, Shanghai, China (GRID:grid.24516.34) (ISNI:0000 0001 2370 4535)
15 Stomatological Hospital of Chongqing Medical University, Department of Endodontics, Chongqing, China (GRID:grid.459985.c)
16 First Affiliated Hospital of Xinjiang Medical University, and College of Stomatology of Xinjiang Medical University, Department of Endodontics, Urumqi, China (GRID:grid.412631.3)
17 First Affiliated Hospital of Harbin Medical University, Department of Endodontics, Schoolof Stomatology, Harbin, China (GRID:grid.412596.d) (ISNI:0000 0004 1797 9737)
18 The Affiliated Stomatological Hospital of Nanchang University, Department of Endodontics, Nanchang, China (GRID:grid.260463.5) (ISNI:0000 0001 2182 8825)
19 Zunyi Medical University, Key Laboratory of Oral Disease Research, School of Stomatology, Zunyi, China (GRID:grid.417409.f) (ISNI:0000 0001 0240 6969)
20 Wenzhou Medical University, Department of Endodontics, School and Hospital of Stomatology, Wenzhou, China (GRID:grid.268099.c) (ISNI:0000 0001 0348 3990)
21 Central South University, Department of Cariology and Endodontics, Xiangya Stomatological School, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164)
22 Cancer Center of Zhejiang University, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, China (GRID:grid.452802.9)
23 Fujian Medical University, School and Hospital of Stomatology, Fuzhou, China (GRID:grid.256112.3) (ISNI:0000 0004 1797 9307)