Abstract

Background

Despite recent advances in the diagnosis and treatment of oral cancer, relative survival rates have not changed significantly. Moringa oleifera (M. oleifera) Lam. is one such plant with its anticancer properties being proved in its leaves, stem, flowers but no studies are yet reported proving the anticancer property of its seed oil on oral cancer. This study aimed to evaluate the anti-proliferative and cytotoxic effect of M. oleifera seed oil against two Oral squamous cell carcinoma cell lines CAL27 and SCC15 using MTT assay.

Results

2D GC-TOF Mass spectrometry revealed a total of 199 compounds, among which the majority were alkanes (68.2016%) and fatty acid esters (11.1399%). The MTT assay report showed good dose-dependent activity. A significant reduction in cell viability within 24 h with IC50 value of 17.78 µg/mL and 24.28 µg/mL for all treatment groups was observed for both the cell lines CAL27 and SCC15.

Conclusion

MTT assay showed a significant decrease in cell viability with an increase in the oil dose, thereby revealing the cytotoxic and anti-proliferative activity of M. oleifera seed oil on oral cancer cell lines namely CAL27and SCC15. The results of this study indicate that M. oleifera seed oil can be used as a potent anti-cancer agent in the treatment of Oral cancer.

Details

Title
Anti-cancer activity of Moringa oleifera Lam. seed oil on oral cancer
Author
Das, Moumita 1   VIAFID ORCID Logo  ; Mohanty, Jatindra Nath 2   VIAFID ORCID Logo  ; Bhuyan, Sanat Kumar 3   VIAFID ORCID Logo  ; Bhuyan, Ruchi 4   VIAFID ORCID Logo 

1  Siksha ‘O’ Anusandhan (Deemed to be University), Department of Medical Research, IMS and SUM Hospital, Bhubaneswar, India (GRID:grid.412612.2) (ISNI:0000 0004 1760 9349) 
2  Centurion University of Technology and Management, School of Applied Sciences, Ramachandrapur, Jatni, India (GRID:grid.460921.8) 
3  Siksha ‘O’ Anusandhan (Deemed to be University), Department of Oral Medicine and Radiology, Institute of Dental Science, Bhubaneswar, India (GRID:grid.459611.e) (ISNI:0000 0004 1774 3038) 
4  Siksha ‘O’ Anusandhan (Deemed to be University), Department of Medical Research, IMS and SUM Hospital, Bhubaneswar, India (GRID:grid.412612.2) (ISNI:0000 0004 1760 9349); Siksha ‘O’ Anusandhan (Deemed to be University), Department of Oral Pathology and Microbiology and Department of Medical Research, IMS and SUM Hospital, Bhubaneswar, India (GRID:grid.412612.2) (ISNI:0000 0004 1760 9349) 
Pages
25
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
ISSN
23148535
e-ISSN
23148543
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43088-024-00475-z
ProQuest document ID
2957630177
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.